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Trazodone

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Identification
Molecular formula
C19H22N4O3
CAS number
19794-93-5
IUPAC name
N-[2-[4-[2-(3,4-dimethoxyphenyl)ethyl]piperazin-1-yl]phenyl]acetamide
State
State

At room temperature, trazodone is in a solid state.

Melting point (Celsius)
86.00
Melting point (Kelvin)
359.15
Boiling point (Celsius)
353.20
Boiling point (Kelvin)
626.35
General information
Molecular weight
408.50g/mol
Molar mass
408.4900g/mol
Density
1.2612g/cm3
Appearence

Trazodone appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[2-[4-[2-(3,4-dimethoxyphenyl)ethyl]piperazin-1-yl]phenyl]acetamide

N-[2-[4-[2-(3,4-dimethoxyphenyl)ethyl]piperazin-1-yl]phenyl]acetamide is a compound with particular solubility characteristics worth exploring. Understanding solubility is crucial because it affects the compound's bioavailability, stability, and overall effectiveness.

Key Points about Solubility:

  • Solvent Type: The solubility of this compound is likely to be influenced by its polarity. Compounds that are more polar tend to be soluble in polar solvents (like water), whereas non-polar compounds have better solubility in non-polar solvents (such as organic solvents).
  • Temperature Dependence: Generally, the solubility of solid compounds increases with temperature. It's important to consider the temperature at which solubility is measured.
  • pH Sensitivity: As an amide, the solubility might also be affected by the pH of the solution. Certain functional groups can ionize or deprotonate, altering solubility.
  • Interactions with Solutes: The presence of other solutes can either enhance or hinder solubility through phenomena such as salting in or salting out.

As one quote goes, "solubility is not merely a property, but a bridge to understanding the behavior of molecules." Therefore, exploring the solubility of N-[2-[4-[2-(3,4-dimethoxyphenyl)ethyl]piperazin-1-yl]phenyl]acetamide helps researchers grasp how it interacts in various environments.

In conclusion, the solubility profile of this compound is multifaceted and could reveal valuable insights, necessitating thorough experimentation and analysis for deeper understanding.

Interesting facts

Intriguing Facts About N-[2-[4-[2-(3,4-dimethoxyphenyl)ethyl]piperazin-1-yl]phenyl]acetamide

N-[2-[4-[2-(3,4-dimethoxyphenyl)ethyl]piperazin-1-yl]phenyl]acetamide, often simply referred to in research as a compound of interest, holds significant potential in various fields, particularly in pharmacology and medicinal chemistry. Here are some noteworthy points to consider:

  • Pharmacological Significance: This compound is often studied for its potential activities as an antagonist or inhibitor of certain receptors in the brain, which might have implications for treating psychological disorders.
  • Structural Features: The presence of the piperazine ring is notable; piperazine derivatives are well-known for their varied biological activities, including antidepressant and anti-anxiety effects.
  • Dimethoxy Phenyl Group: The 3,4-dimethoxyphenyl moiety adds significant lipophilicity, which can enhance the ability of the compound to cross the blood-brain barrier effectively.
  • Research Applications: Known to exhibit affinity for multiple receptor subtypes, the compound is often a focus in studies aimed at developing new therapeutic agents for mental health conditions.
  • Future Potential: As research progresses, this compound could pave the way for novel treatments or lead to the development of better-targeted medications with fewer side effects.

In summary, N-[2-[4-[2-(3,4-dimethoxyphenyl)ethyl]piperazin-1-yl]phenyl]acetamide illustrates the exciting intersections of organic chemistry and pharmacology. As scientists continue to explore its properties, this compound may provide valuable insights into developing therapies that impact mental health and well-being.

Synonyms
BRN 0630051
ACETANILIDE, 2'-(4-(3,4-DIMETHOXYPHENETHYL)-1-PIPERAZINYL)-
1250-37-9
2'-(4-(3,4-Dimethoxyphenethyl)-1-piperazinyl)acetanilide
DTXSID30154545
DTXCID3077036
5-23-02-00161 (beilstein handbook reference)