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Fentanyl

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Identification
Molecular formula
C22H28N2O
CAS number
437-38-7
IUPAC name
N-[2-[4-[2-(diethylamino)ethoxy]-4-phenyl-1-piperidyl]ethyl]aniline
State
State

Fentanyl is mainly encountered as a solid in the form of a powder or crystalline substance at room temperature. For medical use, it's often found in transdermal delivery systems or injectable solutions.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
457.00
Boiling point (Kelvin)
730.15
General information
Molecular weight
336.48g/mol
Molar mass
336.4820g/mol
Density
1.2030g/cm3
Appearence

Fentanyl typically appears as a white or off-white powder in its pure form. It can also manifest in other forms such as liquid or may be pressed into tablets or mixed with other substances for illicit use. In pharmaceutical forms, it is available as a lozenge, nasal spray, or transdermal patch.

Comment on solubility

Solubility of N-[2-[4-[2-(diethylamino)ethoxy]-4-phenyl-1-piperidyl]ethyl]aniline

The solubility of N-[2-[4-[2-(diethylamino)ethoxy]-4-phenyl-1-piperidyl]ethyl]aniline in various solvents is an essential consideration for its application in pharmaceutical formulations and chemical reactions. This compound is characterized by a complex structure that impacts its solubility profile:

  • Polar Solvents: Due to the presence of the ethoxy and amino groups, the compound may exhibit some degree of solubility in polar solvents such as water and ethanol. However, the overall solubility is likely to be limited.
  • Non-Polar Solvents: Given its hydrophobic aromatic rings, N-[2-[4-[2-(diethylamino)ethoxy]-4-phenyl-1-piperidyl]ethyl]aniline may show increased solubility in non-polar organic solvents like dichloromethane and chloroform.
  • pH Dependency: The solubility can significantly depend on the pH of the solution due to the protonation of the amino groups, which affects the ionic character and, in turn, the solubility.

In summary, while this compound has the potential for solubility in a range of solvents, its specific solubility behavior is contingent upon various factors including:

  1. Type and polarity of the solvent
  2. Temperature
  3. pH levels

Understanding these parameters is crucial for optimizing its use in medicinal chemistry and related fields. Thus, experimenting with different solvents under controlled conditions is recommended to find the most suitable dissolving medium.

Interesting facts

Interesting Facts about N-[2-[4-[2-(diethylamino)ethoxy]-4-phenyl-1-piperidyl]ethyl]aniline

N-[2-[4-[2-(diethylamino)ethoxy]-4-phenyl-1-piperidyl]ethyl]aniline, often referred to in academic circles by its functional name, represents a fascinating class of compounds known for their diverse applications in medicinal chemistry. Here are some intriguing facts about this compound:

  • Medicinal Potential: This compound is frequently studied for its potential use as a therapeutic agent in treating various neurological disorders. Its structure indicates a robust interaction with receptor sites in the brain.
  • Structure and Activity: The presence of diethylamino and piperidyl groups suggests that it may display significant activity due to its ability to traverse biological membranes and interact with different targets, making it a subject of interest in pharmacology.
  • Research Applications: Researchers are continuously exploring this compound in the context of drug design and development. Its structure-activity relationship (SAR) is crucial for understanding how slight modifications can impact efficacy and safety.
  • Complex Interaction: The various functional groups in its structure may enable intricate interactions with biological macromolecules, enhancing the compound's potential to act as a modulator for neurotransmitter systems.
  • Historical Context: Compounds with similar structures have historically paved the way for important discoveries in fields such as psychopharmacology, influencing how we approach treatments for anxiety, depression, and other mood disorders.
  • Synthetic Pathways: The synthesis of this compound involves multistep reactions, showcasing the fascinating complexity of organic chemistry that allows scientists to create highly selective and efficient drugs.

In summary, N-[2-[4-[2-(diethylamino)ethoxy]-4-phenyl-1-piperidyl]ethyl]aniline serves not only as a point of interest in academic research but also highlights the innovative spirit of modern chemistry in unraveling the complexities of medicine and drug design.

Synonyms
DIAMOCAINE
27112-37-4
diamocaina
Diamocaine [INN:BAN]
UNII-I3I4XCR66J
I3I4XCR66J
DIAMOCAINE [INN]
DTXSID30181573
1-(2-ANILINOETHYL)-4-(2-(DIETHYLAMINO)ETHOXY)-4-PHENYLPIPERIDINE
4-(2-(DIETHYLAMINO)ETHOXY)-N,4-DIPHENYL-1-PIPERIDINEETHANAMINE
diamocainum
RefChem:132646
DTXCID70104064
N-[2-[4-[2-(diethylamino)ethoxy]-4-phenylpiperidin-1-yl]ethyl]aniline
CHEMBL2110911
SCHEMBL29358950
NS00122645
Q27280330