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Flunarizine

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Identification
Molecular formula
C26H26F2N2
CAS number
52468-60-7
IUPAC name
N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline
State
State

At room temperature, Flunarizine is in a solid state.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
660.15
Boiling point (Kelvin)
933.30
General information
Molecular weight
404.50g/mol
Molar mass
404.5130g/mol
Density
1.2120g/cm3
Appearence

Flunarizine is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline

N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline is a complex organic compound that exhibits unique solubility characteristics. Understanding its solubility is crucial for applications in pharmaceutical formulations and chemical synthesis.

General Solubility Behavior

The solubility of this compound can be influenced by various factors, such as:

  • Polarity: The presence of several aromatic rings and a piperazine moiety suggests a degree of hydrophobicity, which typically results in lower solubility in water.
  • Temperature: Increased temperatures may enhance solubility due to greater molecular movement, potentially overcoming intermolecular forces.
  • Solvent Type: Solubility is likely to be higher in organic solvents (e.g., ethanol, DMSO) compared to polar solvents like water. The compound's lipophilic nature encourages dissolution in non-polar environments.

Practical Implications

In practical terms, when working with N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline:

  • It is likely to be sparingly soluble in aqueous solutions.
  • It’s advisable to use organic solvents for dissolving the compound for experimental procedures.
  • Understanding its solubility can aid in optimizing conditions for drug delivery systems or when conducting synthesis in organic chemistry.

In conclusion, while N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline presents some challenges in terms of solubility, a closer examination of its properties can lead to effective methods for utilization in various scientific endeavors. As the saying goes, "Solubility is key to reactivity!" Understanding and manipulating this characteristic will enhance experimental outcomes.

Interesting facts

Interesting Facts about N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline

N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline is a fascinating compound with unique structural characteristics and potential applications. As a hybrid molecule, it combines a piperazine ring with an extended butyl chain, which plays a crucial role in its properties. Here are some intriguing insights about this compound:

  • Versatile molecular structure: The presence of multiple functional groups in its structure allows for diverse interactions with biological systems, making it a candidate for drug design.
  • Fluorine influence: The incorporation of 4-fluorophenyl moieties enhances lipophilicity, potentially improving membrane permeability, which is crucial in pharmaceutical applications.
  • Neurochemical implications: Compounds similar to this one are often studied for their effects on neurotransmitter systems, particularly in the context of anxiety and depression treatments.
  • Example in research: Researchers exploring this compound often look at its binding affinity for various receptors, which can reveal its applicability in areas such as psychiatry and neurology.
  • Structure-activity relationship (SAR): The design of such compounds emphasizes the importance of understanding how subtle changes in molecular structure impact biological activity.

This compound not only serves as an example of the intricacies involved in drug design but also highlights the ongoing importance of chemistry in medical advancements. As scientists continue to explore its properties and potential, N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline stands as a testament to the power of innovative chemical research!

Synonyms
Difluanazine
DIFLUANINE
Difluanazina
Difluanazin
Difluanazine [INN]
Difluanazinum
UNII-0G412821A8
DTXSID10203727
1-(2-Anilinoethyl)-4-(4,4-bis(p-fluorophenyl)butyl)piperazine
1-PIPERAZINEETHANAMINE, 4-(4,4-BIS(4-FLUOROPHENYL)BUTYL)-N-PHENYL-
DTXCID40126218
5522-39-4
N-[2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]ethyl]aniline
0G412821A8
N-(2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}ethyl)aniline
SCHEMBL1813120
CHEMBL2110931
AKOS015903106
NS00122353
EN300-651252
Q27236738
Z2242164983