Indomethacin | Solubility of Things

Identification

Molecular formula

C₁₉H₁₆ClNO₄

CAS number

53-86-1

IUPAC name

N-[2-(4-acetamidophenyl)ethyl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetamide

State

At room temperature, Indomethacin is a solid substance.

Melting point (Celsius)

158.00

Melting point (Kelvin)

431.15

Boiling point (Celsius)

645.50

Boiling point (Kelvin)

918.65

General information

Molecular weight

357.79g/mol

Molar mass

357.7890g/mol

Density

1.3750g/cm³

Appearence

Indomethacin typically appears as a white to yellow crystalline powder. It is sparsely soluble in water and light-sensitive.

Comment on solubility

Solubility of N-[2-(4-acetamidophenyl)ethyl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetamide

The solubility of the compound N-[2-(4-acetamidophenyl)ethyl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetamide (C₁₉H₁₆ClNO₄) can be described through various factors that influence its behavior in different solvents. Overall, its solubility is determined by the presence of functional groups and the overall structure of the molecule.

Factors Affecting Solubility:

Polarity: The presence of polar functional groups, such as the acetamide and methoxy groups, can enhance solubility in polar solvents like water.
Hydrophobic Regions: The hydrophobic aromatic rings may hinder solubility in highly polar solvents and favor solubility in organic solvents such as ethanol or dichloromethane.
Temperature: Increasing temperature often increases the solubility of organic compounds; thus, warmer conditions may facilitate better dissolution of this compound.

In general, one might expect this compound to demonstrate moderate solubility in organic solvents, while potentially being less soluble in water due to its complex structure and hydrophobic characteristics. This interaction of various functional groups suggests that optimization of solvent choice is key for effective use of this compound in applications where solubility is essential.

Interesting facts

Interesting Facts about N-[2-(4-acetamidophenyl)ethyl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetamide

This intriguing compound, often referenced in pharmacological studies, exhibits fascinating properties and potential biological applications. Here are some fascinating facts that highlight its importance in the field of chemistry and medicinal research:

Therapeutic Potential: The structure of this compound suggests it may interact with various biological targets, making it a candidate for drug development. Its indole backbone is often associated with numerous pharmacological activities.
Structure-Activity Relationship: The presence of both the acetamide and chlorobenzoyl groups signifies that this compound may possess unique mechanisms of action that can be tailored for specific therapeutic outcomes.
Indole Chemistry: Indoles, like the one present in this compound, are notable for their occurrence in several natural products, particularly in the realm of medicinal chemistry. They can serve as key scaffolds for developing new pharmaceuticals.
Potential Inhibition: Preliminary studies may suggest the compound could be active against various targets, including cancer cell lines, due to its structural motifs which often influence cell signaling pathways.
Research Implications: The versatility of this compound opens avenues for various synthesis routes and modifications, allowing chemists to explore a wide range of derivatives with potentially enhanced efficacy and reduced side effects.

Overall, N-[2-(4-acetamidophenyl)ethyl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetamide not only showcases the elegance of organic synthesis but also emphasizes the intricate relationship between structure and biological activity. As researchers continue to unravel its properties, we may discover even more applications for this intriguing compound.

Synonyms

N-(4-Acetamidophenyl)indomethacinamide