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Chloramphenicol

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Identification
Molecular formula
C11H12Cl2N2O5
CAS number
56-75-7
IUPAC name
N-[2-(4-aminophenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide
State
State

Chloramphenicol is a solid at room temperature.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
323.13g/mol
Molar mass
323.1320g/mol
Density
1.7000g/cm3
Appearence

Chloramphenicol appears as a white to grayish-white crystalline solid. It is odorless, and its appearance is characterized by its crystalline texture.

Comment on solubility

Solubility of N-[2-(4-aminophenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide (C11H12Cl2N2O5)

This compound exhibits a unique solubility profile owing to its complex structure. The presence of multiple functional groups plays a significant role in its interaction with solvents:

  • Aromatic amine group: The 4-aminophenyl segment can enhance solubility in polar solvents due to its ability to engage in hydrogen bonding.
  • Hydroxyl groups: The two hydroxymethyl and hydroxy functionalities improve water solubility significantly, allowing the compound to dissolve in aqueous environments.
  • Chloroacetamide moiety: The presence of chlorine atoms is known to affect the overall polarity, making the compound more soluble in organic solvents.

In general, N-[2-(4-aminophenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide may demonstrate:

  1. Moderate solubility in water due to the dual hydroxyl groups, facilitating interactions with water molecules.
  2. Higher solubility in organic solvents, particularly those with polar characteristics, such as ethanol or methanol.
  3. Limitations in aliphatic solvents where the compound may precipitate due to reduced intermolecular interactions.

As a result, understanding the solubility of this compound is crucial for its applications in various chemical processes, as well as for determining its behavior in biological systems.

Interesting facts

Interesting Facts about N-[2-(4-Aminophenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide

N-[2-(4-aminophenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide is a fascinating compound with a variety of characteristics and applications. Here are some intriguing points about this compound:

  • Structure and Composition: This compound contains two chlorine atoms, which contribute to its reactivity and biological activity. The presence of an amine group makes it a key player in various chemical reactions.
  • Biological Significance: Compounds like this one often exhibit antimicrobial and anti-cancer properties, potentially serving as lead compounds in drug development. The specific activities can be attributed to the unique combination of functional groups within its structure.
  • Versatility in Applications: Due to its structural properties, this compound has applications in pharmaceuticals, agricultural chemicals, and as a building block in organic synthesis.
  • Synthesis and Reaction: The synthesis of this compound may involve multi-step organic reactions, showcasing the intricacies of organic chemistry. Understanding these reactions can enhance skills in synthetic strategy development.

As noted by renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This aligns perfectly with the exploration of compounds like N-[2-(4-aminophenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide, where understanding its diverse potential can lead to innovative solutions in chemistry and beyond.

In summary, this compound is not just an assemblage of atoms; it is a testament to the complexity and beauty of chemical interactions, revealing endless opportunities for research and application.

Synonyms
17364-04-4
N-[1-(4-aminophenyl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide
P-AMINO-AMPHENICOL
SCHEMBL10777805
DTXSID30274439
DTXSID40876423
PD040502