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Fentanyl Hydrochloride

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Identification
Molecular formula
C22H28ClNO2
CAS number
990-73-8
IUPAC name
N-[2-(4-hydroxy-4-phenyl-1-piperidyl)-1-methyl-ethyl]-N-phenyl-furan-2-carboxamide;hydrochloride
State
State

At room temperature, fentanyl hydrochloride is a solid. In healthcare settings, it is often stocked in its powder form, and can be dissolved for intravenous use or formulated into tablets, patches, or lozenges.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
212.00
Boiling point (Kelvin)
485.15
General information
Molecular weight
372.93g/mol
Molar mass
372.9290g/mol
Density
1.1740g/cm3
Appearence

Fentanyl hydrochloride typically appears as a white to off-white powder. In its pure form, it is crystalline, and may have a slightly glossy appearance. The compound is highly potent and should be handled with care, as it can be easily absorbed through the skin and cause toxicity.

Comment on solubility

Solubility of N-[2-(4-hydroxy-4-phenyl-1-piperidyl)-1-methyl-ethyl]-N-phenyl-furan-2-carboxamide;hydrochloride (C22H28ClNO2)

The solubility characteristics of N-[2-(4-hydroxy-4-phenyl-1-piperidyl)-1-methyl-ethyl]-N-phenyl-furan-2-carboxamide;hydrochloride are quite intriguing. This compound showcases distinct solubility properties that depend heavily on several factors:

  • Solvent Type: The solubility of this compound is generally higher in organic solvents such as ethanol and dimethyl sulfoxide (DMSO) due to the hydrophobic furan ring and phenyl groups.
  • pH Dependency: Being a hydrochloride salt, its solubility is influenced by the pH of the solution. Under acidic conditions, the solubility might increase due to the ionization of the ammonium group.
  • Temperature Effects: Typically, an increase in temperature leads to greater solubility in many organic compounds; thus, heating the solution may enhance the dissolution rate.
  • Crystal Form: The specific crystalline form of the compound can also play a pivotal role in determining solubility; polymorphic forms can exhibit different solubility behaviors.

It is noteworthy that compounds like this one often exhibit limited solubility in water, which can pose challenges in formulation strategies for pharmacological applications. As stated, "The chemistry of solubility is essential in determining the bioavailability of pharmaceutical compounds." Therefore, understanding these solubility dynamics is crucial for optimizing its use in various settings.

Interesting facts

Interesting Facts about N-[2-(4-hydroxy-4-phenyl-1-piperidyl)-1-methyl-ethyl]-N-phenyl-furan-2-carboxamide; hydrochloride

This compound is a fascinating example of a hydrochloride salt of an amide, and it showcases the intricate relationships between chemical structure and biological activity. Here are some key points to consider:

  • Medicinal Chemistry: The presence of the piperidine ring along with a furan-2-carboxamide structure is indicative of potential pharmaceutical applications. Such compounds often demonstrate diverse biological activity.
  • Hydroxyl Group Impact: The 4-hydroxy group on the phenyl ring is known to enhance solubility and may also play a crucial role in receptor interactions, potentially affecting the efficacy of the compound.
  • Research Applications: Researchers are particularly interested in compounds featuring furan rings, as they have been reported to exhibit anti-inflammatory, analgesic, and anti-cancer properties.
  • Chloride Role: The hydrochloride form of the compound not only improves stability but also influences its pharmacokinetics, making it easier to handle in solubilized forms.

As a chemistry student, you might find it intriguing that compounds like this one require precise synthesis and analysis methods to explore their potential applications. Understanding their structure-activity relationships is crucial, and the interplay of various functional groups offers a glimpse into exciting possibilities for drug discovery and development.

In the words of a prominent chemist, “The beauty of chemistry lies in its ability to create and understand new compounds, leading to advancements in medicine and technology.”


Synonyms
53-27-0
2-Furamide, N-(2-(4-hydroxy-4-phenylpiperidino)-1-methyl)ethyl-N-phenyl-, hydrochloride
DTXSID80967465
2-Furanilide, N-(2-(4-hydroxy-4-phenylpiperidino)-1-methylethyl)-, monohydrochloride
N-[1-(4-Hydroxy-4-phenylpiperidin-1-yl)propan-2-yl]-N-phenylfuran-2-carboxamide--hydrogen chloride (1/1)