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N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide

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Identification
Molecular formula
C12H12FN3O1S1
CAS number
956025-11-5
IUPAC name
N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide
State
State

At room temperature, N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide is a solid. It is generally stable under normal conditions and does not vaporize easily.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
522.00
Boiling point (Kelvin)
795.15
General information
Molecular weight
282.30g/mol
Molar mass
282.2990g/mol
Density
1.4600g/cm3
Appearence

N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide typically appears as a crystalline solid. The exact color and texture can vary, but it is generally reported as a light-colored, off-white material.

Comment on solubility

Solubility of N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide

N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide, with the chemical formula C12H12FN3O1S1, exhibits a range of solubility characteristics that are important for its application in various fields. Understanding its solubility can aid in predicting its behavior in biological systems and during formulation.

Key Solubility Factors:

  • Polarity: The presence of polar functional groups, such as the carboxamide moiety, enhances solubility in polar solvents like water.
  • Hydrophobic Regions: The thiazole and phenyl components contribute hydrophobic characteristics, which may lead to reduced solubility in aqueous environments.
  • Solvent Interaction: Solubility may significantly differ when interacting with organic solvents (e.g., ethanol or DMSO), where its hydrophobic regions can promote solvation.
  • Temperature Effects: Generally, solubility increases with temperature; thus, heating may improve the dissolution of this compound in various solvents.

The overall solubility of this compound can be characterized as moderate due to the balancing act between polar and non-polar characteristics. As noted, solubility is context-dependent, and factors such as pH and the presence of co-solvents should also be considered. Understanding these factors is crucial for practical applications, such as in drug delivery and design.

Interesting facts

Interesting Facts about N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide

N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide is a fascinating compound belonging to the thiazole family, which contains a five-membered ring structure incorporating both nitrogen and sulfur.

Key Characteristics

  • Pharmacological Potential: This compound has attracted attention in medicinal chemistry due to its potential therapeutic applications. Specifically, its thiazole backbone plays a crucial role in many biologically active compounds, including antibiotics and anti-cancer agents.
  • Fluorine Influence: The incorporation of a fluorine atom is significant; it can enhance the compound's lipophilicity, affecting how it interacts within biological systems and potentially improving its efficacy as a drug.
  • Structure-Activity Relationship: The specific arrangement of the aminoethyl and the carboxamide groups could influence the compound’s activity, making it an interesting subject for studies in structure-activity relationships (SAR).

Applications in Research

Researchers are exploring thiazole derivatives for their diverse biological activities. As such, this compound may contribute to the development of new pharmaceuticals targeting various diseases.

A Scientific Quote

As noted by many chemists, "The design of novel thiazole compounds can lead to significant breakthroughs in drug discovery." This encapsulates the excitement surrounding compounds like N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide.

In summary, N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide is a compound rich with potential due to its unique structure, promising applications in medicinal chemistry, and its role in ongoing research aimed at discovering new therapeutic agents. The exploration of this compound opens doors to deeper understanding and innovation within the field of chemistry.

Synonyms
127500-84-9
N-(2-Aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide
Ro 41-1049
Ro-41-1049
4-Thiazolecarboxamide, N-(2-aminoethyl)-5-(3-fluorophenyl)-
N-(2-Aminoethyl)-5-(3-fluorophenyl)-4-thiazolecarboxamide
n-(2-aminoethyl)-5-(3-fluorophenyl)-1,3-thiazole-4-carboxamide
UNII-40Y4916ZJ4
DTXSID10155590
40Y4916ZJ4
NCGC00015880-01
Lopac-R-107
Lopac0_001113
SCHEMBL6866198
CHEMBL1488153
DTXCID0078081
AKOS016007486
CCG-205189
SDCCGSBI-0051082.P002
NCGC00015880-02
NCGC00015880-03
NCGC00162345-01
DB-352217
Q27258360
N-(2-aminoethyl)-5-(m-fluorophenyl)-4-thiazole carboxamide