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N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide

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Identification
Molecular formula
C12H13ClN2O2S
CAS number
73240-63-0
IUPAC name
N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide
State
State

At room temperature, N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide is in a solid state, often found as a crystalline powder.

Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
442.00
Boiling point (Kelvin)
715.15
General information
Molecular weight
318.78g/mol
Molar mass
318.7800g/mol
Density
1.4000g/cm3
Appearence

N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide typically appears as a pale yellow solid. It may appear slightly off-white depending on the batch or purity level. The compound is usually supplied in powder form.

Comment on solubility

Solubility of N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide (C12H13ClN2O2S)

N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide displays distinct solubility characteristics that are influenced by its molecular structure. The compound's solubility can be summarized as follows:

  • Polar Solvents: Generally, the presence of the sulfonamide group enhances the polarity of the molecule, promoting better solubility in polar solvents such as water.
  • Non-Polar Solvents: Conversely, the naphthalene ring contributes to the molecule's hydrophobic regions, which can hinder solubility in non-polar solvents.
  • pH Dependency: The solubility may also vary with pH, as protonation of the amino group can increase solubility in aqueous solution.

As a rule of thumb, compounds with significant ionic or polar functionalities like the sulfonamide group tend to be more soluble in water, while aromatic rings might increase insolubility in organic solvents. Thus, for experimental purposes, it is recommended to assess solubility under varying conditions to fully understand its behavior in different environments.

Interesting facts

Interesting Facts about N-(2-Aminoethyl)-5-chloro-naphthalene-1-sulfonamide

N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide, commonly referred to in scientific literature as an important organic compound, has several intriguing attributes worth noting:

  • Pharmaceutical Relevance: This compound is often studied for its potential application as a pharmaceutical agent. It belongs to a class of sulfonamides, compounds known for their effectiveness as antibiotics and antibacterial agents.
  • Structure and Function: The unique naphthalene ring within the compound provides significant aromatic stability, which can enhance its biologically relevant properties.
  • Chlorine Substitution: The presence of chlorine in the molecular structure contributes to the compound's reactivity and can influence its biological activity, making it a subject of investigation in drug design.
  • Research Focus: Ongoing research often explores how modifications of the aminoethyl and sulfonamide groups affect the compound's pharmacological profile, potentially leading to novel therapeutic agents.
  • Historical Context: Sulfonamides made their mark in history as some of the first synthetic antibiotics. N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide continues this legacy, showing promise in modern medicinal chemistry.

In summary, N-(2-aminoethyl)-5-chloro-naphthalene-1-sulfonamide is a fascinating substance that bridges historical significance with contemporary scientific inquiry. Its complex structure and potential pharmacological applications make it a noteworthy topic for any chemistry enthusiast or professional.

Synonyms
N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide
83298-75-3
CHEMBL219301
Tocris-0366
CBiol_002054
BSPBio_001382
A-3
SCHEMBL2739414
DTXSID00274345
CHEBI:107666
Bio1_000340
Bio1_000829
Bio1_001318
HMS1791F04
HMS1989F04
HMS3402F04
N-(2-AMINOETHYL)-5-CHLORO-NAPHTHALENE-1-SULFONAMIDE
BDBM50375645
SDCCGSBI-0633780.P001
NCGC00024555-01
NCGC00024555-02
NCGC00024555-03
NCGC00024555-04
NCGC00024555-05
NCGC00024555-06
N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide
BRD-K51215422-001-02-3
BRD-K51215422-003-01-1
Q27185988
5-Chloro-naphthalene-1-sulfonic acid, (2-amino-ethyl)-amide