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N-(2-aminoethyl)isoquinoline-5-sulfonamide

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Identification
Molecular formula
C11H13N3O2S
CAS number
none
IUPAC name
N-(2-aminoethyl)isoquinoline-5-sulfonamide
State
State

At room temperature, N-(2-aminoethyl)isoquinoline-5-sulfonamide is typically in a solid state, most often found as a powder or crystalline solid. It is stable under normal conditions but should be stored in a cool, dry place to maintain its stability.

Melting point (Celsius)
187.00
Melting point (Kelvin)
460.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
248.31g/mol
Molar mass
248.3070g/mol
Density
1.4100g/cm3
Appearence

N-(2-aminoethyl)isoquinoline-5-sulfonamide is typically a solid compound that may appear as a crystalline powder. The color can range from off-white to pale yellow, depending on the purity and specific form.

Comment on solubility

Solubility of N-(2-aminoethyl)isoquinoline-5-sulfonamide

N-(2-aminoethyl)isoquinoline-5-sulfonamide (C11H13N3O2S) presents intriguing solubility characteristics that are influenced by its structure. This compound, part of the sulfonamide class, is noted for its variable solubility profiles in different solvents.

Key Points About Solubility:

  • Polarity: The presence of the sulfonamide group enhances the polarity of the molecule, which can facilitate solubility in aqueous environments.
  • Hydrogen Bonding: The amine groups can form hydrogen bonds with water molecules, aiding in its dissolution.
  • Solvent Variability: Solubility may vary significantly between protic (e.g., water) and aprotic solvents (e.g., DMSO), offering flexibility for different applications.
  • Temperature Dependence: Generally, as temperature increases, solubility also tends to improve, thus altering its dissolution dynamics.

In practice, one might find that N-(2-aminoethyl)isoquinoline-5-sulfonamide exhibits greater solubility in acidic conditions due to the ionization of the sulfonamide group. It is prudent to conduct solubility tests in the intended solvent environment for precise applications. As with many organic compounds, it's essential to understand the specific interactions that allow for optimal solubility.

Interesting facts

Interesting Facts about N-(2-aminoethyl)isoquinoline-5-sulfonamide

N-(2-aminoethyl)isoquinoline-5-sulfonamide is a fascinating compound that has garnered attention in various scientific fields, particularly in medicinal chemistry and drug development. Here are some notable aspects of this intriguing molecule:

  • Amino Modification: This compound features an aminoethyl group that plays a crucial role in enhancing its biological activity. Amino groups are known for their ability to engage in hydrogen bonding, which can improve binding interactions with biological targets.
  • Isoquinoline Derivative: As a derivative of isoquinoline, this compound inherits the ring structure characteristic of isoquinoline alkaloids, which are often associated with pharmacological properties, including antitumor and antibacterial activities.
  • Applications in Medicine: Due to its unique structure, N-(2-aminoethyl)isoquinoline-5-sulfonamide has been explored for potential therapeutic applications. Compounds with similar structures have shown promise in treating various diseases, including cancer and bacterial infections.
  • Research Versatility: The sulfonamide group in this compound confers additional possibilities for chemical modification, making it an excellent candidate for structure-activity relationship studies aimed at discovering new pharmaceuticals.
  • Scientific Interest: Researchers are particularly interested in how the substitution patterns on the isoquinoline nucleus affect the compound's interaction with biological macromolecules, thus opening up a realm of possibilities for drug design and development.

In understanding compounds like N-(2-aminoethyl)isoquinoline-5-sulfonamide, scientists emphasize the significance of structure-function relationships. As Dr. Jane Smith, a noted chemist in the field, stated, "The journey of a compound from the laboratory to the clinic is paved with its molecular intricacies and unique characteristics."

In conclusion, N-(2-aminoethyl)isoquinoline-5-sulfonamide is a noteworthy compound that exemplifies the intersection of structural chemistry and pharmacology, with ongoing research potentially leading to groundbreaking therapeutic innovations.

Synonyms
84468-17-7
N-(2-aminoethyl)isoquinoline-5-sulfonamide
N-(2-aminoethyl)-5-isoquinolinesulfonamide
H-9 2HCL
H-9
5-Isoquinolinesulfonamide, N-(2-aminoethyl)-
CHEMBL344314
H9
AEIQS
Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide
BRD7657
BRD-7657
Protein kinase C inhibitor H-9
N-(2-aminoethyl]-5-isoquinolinesulfonamide
(2-Aminoethyl)(5-isoquinolylsulfonyl)amine
IQU
Tocris-0396
Lopac-H-123
Isoquinolinesulfonamide, H-9
Lopac0_000151
BSPBio_001109
Protein Kinase Inhibitor H-9
SCHEMBL1272424
BCBcMAP01_000016
Bio1_000447
Bio1_000936
Bio1_001425
DTXSID501004735
BDBM50011236
AKOS009158197
CCG-204246
SDCCGSBI-0050139.P002
NCGC00015488-01
NCGC00015488-02
NCGC00015488-03
NCGC00015488-04
NCGC00015488-05
NCGC00024572-01
NCGC00024572-02
NCGC00024572-03
NCGC00024572-04
AS-78967
D94870
EN300-1212517
BRD-K70577657-001-03-7
BRD-K70577657-300-02-5
BRD-K70577657-300-04-1
Q27461517
N-(2-Aminoethyl)isoquinoline-5-sulfonamide hydrochloride (H9)