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Acetanilide

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Identification
Molecular formula
C8H9NO
CAS number
103-84-4
IUPAC name
N-(2-aminophenyl)acetamide
State
State

Acetanilide is a solid at room temperature. It is typically presented in crystalline form.

Melting point (Celsius)
114.30
Melting point (Kelvin)
387.45
Boiling point (Celsius)
304.00
Boiling point (Kelvin)
577.15
General information
Molecular weight
135.17g/mol
Molar mass
135.1660g/mol
Density
1.2190g/cm3
Appearence

Acetanilide appears as white or slightly greyish crystalline solid flakes or powder. It is odorless in its pure form but may have a slight aromatic odor if impurities are present. The compound exhibits a shiny texture due to its crystalline structure.

Comment on solubility

Solubility of N-(2-aminophenyl)acetamide

N-(2-aminophenyl)acetamide, also known as 2-acetamidophenylamine, showcases intriguing solubility characteristics that are essential for its applications in various chemical processes.

In terms of solubility, this compound exhibits the following traits:

  • Moderate Solubility in Water: N-(2-aminophenyl)acetamide has a relatively moderate solubility in water, making it useful in biological and chemical contexts where aqueous solutions are necessary.
  • Soluble in Organic Solvents: It is generally soluble in many organic solvents such as ethanol, acetone, and chloroform, which enhances its versatility in organic synthesis.
  • Temperature Dependency: The solubility tends to increase with temperature, a common trait for many organic compounds, thus facilitating processes that require higher thermal conditions.

It is important to note that the solubility of N-(2-aminophenyl)acetamide can be influenced by several factors:

  • pH Levels: Changes in pH can impact the ionization state of the amine group, potentially enhancing or decreasing its solubility in water.
  • Composition of the Solvent: The presence of various solutes or additives in a solvent may either promote or hinder solubility through competitive interactions.
  • Crystallization Conditions: The conditions under which the compound is crystallized can also affect its subsequent solubility behavior in different media.

In conclusion, understanding the solubility of N-(2-aminophenyl)acetamide is crucial for its practical application in chemical research and industry. As the saying goes, “the *solubility* of a compound is the key that unlocks its potential in various applications.”

Interesting facts

Interesting Facts about N-(2-aminophenyl)acetamide

N-(2-aminophenyl)acetamide, also known as 2-Aminoacetanilide, is a fascinating compound that finds its relevance in various fields of chemistry and biology. Here are some noteworthy aspects of this compound:

  • Pharmaceutical Significance: It is often used as a starting material for the synthesis of numerous pharmaceutical compounds. Its structural properties enable it to act as a building block for creating drugs with therapeutic implications.
  • Analgesic Properties: This compound is recognized for its potential analgesic effects. Research has indicated that derivatives of N-(2-aminophenyl)acetamide may help in pain relief, making them valuable for medicinal chemistry.
  • Reaction Intermediate: In organic synthesis, N-(2-aminophenyl)acetamide acts as an important intermediate. It can be transformed into various derivatives through different chemical reactions, contributing significantly to synthetic methodologies.
  • Research Applications: The compound is often studied for its interactions with biological targets. Studies into its structure-activity relationship (SAR) reveal insights into how small changes in its molecular structure can impact its biological activity.
  • Substituent Variability: By altering the substituents on the amino group or the acetamide group, scientists can explore a wide array of derivatives that exhibit different properties, allowing for extensive customization in research applications.

As one delves into the properties and functionalities of N-(2-aminophenyl)acetamide, it's clear that this compound is more than just a simple organic molecule. Its multifaceted applications make it a subject of keen interest for researchers and scientists alike. The exploration of its derivatives continues to unveil new potentials in both synthetic chemistry and pharmacology.

Synonyms
34801-09-7
o-aminoacetanilide
Acetamide, N-(2-aminophenyl)-
N-Acetyl-2-aminoaniline
N-Acetyl-o-phenylenediamine
LB34XRQ95V
2-ACETAMIDOANILINE
NSC 16117
NSC-16117
UNII-LB34XRQ95V
AMINOACETANILIDE, O-
N-(2-Aminophenyl)acetamide
2'-Aminoacetanilide
MFCD00210388
2'-Acetamidoaniline
TimTec1_004882
2'-Aminoacetanilide, 98%
Oprea1_268954
SCHEMBL463597
N-(2-amino-phenyl)-acetamide
N-Acetyl-1,2-phenylenediamine
HMS1547N20
ALBB-006008
NSC16117
BBL002386
STK500749
AKOS000100447
CS-W008938
FA70678
MS-1760
SB75765
SY050887
2 inverted exclamation mark -Aminoacetanilide
A2426
EN300-137656
N10407
AE-641/00627026
Q27890211
Z239120544