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Tenofovir alafenamide

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Identification
Molecular formula
C21H29N6O5P
CAS number
379270-37-8
IUPAC name
N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)propyl]-4-pentyl-pyrrolidine-2-carboxamide
State
State

At room temperature, tenofovir alafenamide is in a solid state.

Melting point (Celsius)
243.00
Melting point (Kelvin)
516.15
Boiling point (Celsius)
570.50
Boiling point (Kelvin)
843.65
General information
Molecular weight
476.51g/mol
Molar mass
476.5090g/mol
Density
1.5613g/cm3
Appearence

Tenofovir alafenamide is typically a white to off-white powder. It is characterized by its crystalline form.

Comment on solubility

Solubility Characteristics

The compound N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)propyl]-4-pentyl-pyrrolidine-2-carboxamide exhibits unique solubility properties that stem from its intricate molecular structure.

Solubility in Different Solvents

This compound's solubility can largely depend on various factors, including:

  • Polarity: Due to the presence of multiple hydroxyl groups, solubility in polar solvents such as water may be favorable.
  • Hydrophobic Interactions: The long pentyl chain may reduce solubility in highly polar environments, making organic solvents like ethanol or methanol more suitable.
  • Temperature: Increased temperature typically enhances solubility, particularly for solid compounds.

Influence of Functional Groups

The incorporation of diverse functional groups results in:

  • The hydroxyl groups providing potential hydrogen bonding with solvents.
  • The bulky aliphatic chain contributing to hydrophobic characteristics, thus influencing solubility behavior.

When discussing solubility, it is essential to note that "like dissolves like." This principle suggests that due to its dual characteristics — both polar and hydrophobic — the compound may demonstrate varying solubility profiles depending on the solvent choice.
In summary, evaluating the solubility of this compound necessitates a comprehensive understanding of its molecular structure, interactions with solvents, and environmental conditions, making it an intriguing subject for further study.

Interesting facts

Interesting Facts about N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)propyl]-4-pentyl-pyrrolidine-2-carboxamide

This compound, with its intricate structure, offers a fascinating glimpse into the world of medicinal chemistry and pharmacology. Here are some noteworthy points:

  • Complex Structure: The compound boasts multiple functional groups, including a carboxamide and several hydroxyl groups, which can play crucial roles in its biological activity.
  • Potential Biological Activity: Compounds featuring pyrrolidine rings are often studied for their potential in drug development due to their ability to mimic natural biomolecules and influence various biochemical pathways.
  • Therapeutic Implications: Given its unique configuration, researchers are exploring its applications in treating conditions that may benefit from modified sugars and sulfur-containing compounds, such as certain metabolic disorders.

The presence of various functional groups allows for interactions with numerous biological targets, which makes this compound an intriguing subject for further studies. According to a well-known chemist, "The complexity of a molecule often mirrors the intricacies of life itself." This emphasizes how even a synthetic compound can exhibit rich biological relevance.

Moreover, the trihydroxy component hints at possible antioxidant properties, while the methylsulfanyl group might enhance the compound's stability and reactivity. As new experimental techniques develop, there is great potential to discover more about how such compounds can lead to innovative therapies.

In summary, N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)propyl]-4-pentyl-pyrrolidine-2-carboxamide represents a compelling intersection of chemistry, biology, and potential therapeutic application.

Synonyms
Mirincamycin
31101-25-4
DTXSID10865581
N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl)propyl]-4-pentylpyrrolidine-2-carboxamide
NS00125631
methyl 7-chloro-6,7,8-trideoxy-6-[(4-pentylprolyl)amino]-1-thiooctopyranoside