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Etodolac

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Identification
Molecular formula
C17H21ClN2O2
CAS number
41340-25-4
IUPAC name
N-(2-chloro-5-ethyl-phenyl)-2-(diethylamino)acetamide
State
State

Etodolac is typically found as a solid at room temperature.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
353.00
Boiling point (Kelvin)
626.15
General information
Molecular weight
287.79g/mol
Molar mass
287.7890g/mol
Density
1.1569g/cm3
Appearence

Etodolac is a white to off-white crystalline powder.

Comment on solubility

Solubility of N-(2-chloro-5-ethyl-phenyl)-2-(diethylamino)acetamide

N-(2-chloro-5-ethyl-phenyl)-2-(diethylamino)acetamide is a compound whose solubility can be influenced by its unique molecular structure. Understanding its solubility is essential for its applications in various fields, including pharmaceuticals. Here are some key points to consider:

  • Polarity: The presence of both polar and non-polar functional groups in the molecule can lead to moderate solubility in polar solvents like water.
  • Solvent Interaction: It may also show good solubility in organic solvents such as ethanol or methanol due to the non-polar diethylamino group.
  • Temperature Dependency: Solubility can vary with temperature; generally, higher temperatures increase solubility.
  • pH Effects: The solubility may also be affected by the pH of the solution, leading to potential changes in ionization.

In summary, the solubility of N-(2-chloro-5-ethyl-phenyl)-2-(diethylamino)acetamide is a multifaceted topic that depends on various factors including solvent type and temperature. As the saying goes, "Like dissolves like," so knowing the nature of the solvents and the compound will lead to better solubility outcomes. Exploring the solubility profile is crucial for effectively using this compound in practical applications.

Interesting facts

Interesting Facts about N-(2-chloro-5-ethyl-phenyl)-2-(diethylamino)acetamide

N-(2-chloro-5-ethyl-phenyl)-2-(diethylamino)acetamide, often referred to in research circles as a compound with intriguing pharmacological properties, holds a special place in the study of medicinal chemistry. Here are some key insights into this fascinating compound:

  • Pharmacological Potential: This compound is often investigated for its potential as a therapeutic agent, particularly in the realm of analgesics and anesthetics. Its structure may offer insights into how compounds can modulate pain pathways.
  • Structure-Activity Relationship (SAR): The presence of the diethylamino group is critical in understanding its interaction with biological targets. Studying such SAR can lead to the development of more effective drugs with fewer side effects.
  • Chlorination Impact: The chlorinated phenyl ring can significantly affect the lipophilicity and bioavailability of the compound, which are essential factors in drug design.
  • Research Applications: Scientists often utilize compounds like this as a starting point to develop new medications. Research findings can lead to synthesis alterations to improve efficacy or reduce toxicity.
  • Receptor Interactions: There is ongoing research into how this compound interacts with various receptors in the body, aiding in understanding various physiological processes.

Moreover, compounds like N-(2-chloro-5-ethyl-phenyl)-2-(diethylamino)acetamide emphasize the importance of interdisciplinary collaboration in medicinal chemistry, where pharmacology meets synthetic organic chemistry. Such collaborations can lead to breakthroughs that could revolutionize how we manage pain and other medical conditions.

As quoted in recent studies, "Understanding the nuances of compound interactions paves the way for innovative therapeutic approaches." Engaging in the study of such compounds is not just about their chemistry; it opens doors to a deeper understanding of biological systems and potential treatments for debilitating illnesses.

Synonyms
BRN 2697132
ACETANILIDE, 2'-CHLORO-2-(DIETHYLAMINO)-5'-ETHYL-
2'-Chloro-2-(diethylamino)-5'-ethylacetanilide
3117-16-6
alpha-Diaethylamino-3-aethyl-6-chlor-acetanilid [German]
DTXSID50185098
alpha-Diaethylamino-3-aethyl-6-chlor-acetanilid
DTXCID60107589