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Etomidate

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Identification
Molecular formula
C14H20ClNO2
CAS number
33125-97-2
IUPAC name
N-(2-chloro-5-ethyl-phenyl)-3-(diethylamino)butanamide
State
State

At room temperature, Etomidate is usually in a solid state as a crystalline powder.

Melting point (Celsius)
76.50
Melting point (Kelvin)
349.65
Boiling point (Celsius)
499.30
Boiling point (Kelvin)
772.45
General information
Molecular weight
244.77g/mol
Molar mass
244.7610g/mol
Density
1.2100g/cm3
Appearence

Etomidate typically appears as a white crystalline powder. It is often used in an injectable form when used in medical settings.

Comment on solubility

Solubility of N-(2-chloro-5-ethyl-phenyl)-3-(diethylamino)butanamide

N-(2-chloro-5-ethyl-phenyl)-3-(diethylamino)butanamide is a compound with varying solubility characteristics, influenced by its functional groups and hydrophobic or hydrophilic nature. Understanding its solubility can guide its application in various fields, particularly in pharmaceuticals and organic synthesis. Here are key points to consider:

  • Solvent Interaction: The compound's solubility is generally higher in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetone, due to the presence of aromatic rings and alkyl groups that enhance hydrophobic interactions.
  • Water Solubility: It is expected to have limited solubility in water because of the bulky and hydrophobic components, which can hinder interactions with polar water molecules.
  • Temperature Dependence: The solubility may increase with temperature, as higher temperatures typically lead to increased molecular movement, enhancing solvation processes.
  • Degree of Ionization: Depending on the pH of the solution, the amide group may exhibit some degree of ionization, which can also affect solubility, especially in biological applications.

In summary, while N-(2-chloro-5-ethyl-phenyl)-3-(diethylamino)butanamide shows promising solubility in certain organic solvents, its limited solubility in water underscores the importance of solvent choice in practical applications. Selecting the right solvent can optimize its use and enhance its effectiveness in various contexts.

Interesting facts

N-(2-chloro-5-ethyl-phenyl)-3-(diethylamino)butanamide

N-(2-chloro-5-ethyl-phenyl)-3-(diethylamino)butanamide is a fascinating compound known for its unique structural characteristics and potential applications. Here are several intriguing aspects of this compound:

  • Diverse Applications: This compound may be explored in pharmaceutical research due to its potential properties that could be beneficial in developing new therapeutic agents. Its chemical structure suggests possible interactions with biological targets that merit investigation.
  • Chirality and Isomerism: The presence of multiple chiral centers in its structure opens up a variety of stereoisomers. This diversity is crucial in medicinal chemistry because different isomers can exhibit significantly different biological activities.
  • Structural Features: The presence of a chloro substituent can influence the electronic properties of the molecule, while the diethylamino group adds to its solubility characteristics and can modulate its reactivity.
  • Research Potential: Compounds like this one are often subject to various in vitro and in vivo studies to assess their pharmacokinetics and pharmacodynamics, leading to potential breakthroughs in drug development.
  • Recent Studies: Research focusing on related compounds has shown promising results in treating various ailments, including cancer and neurological disorders. This emphasizes the importance of continuous exploration in the field of medicinal chemistry.

This compound serves as an excellent example of how small changes in molecular structure can lead to substantive variations in pharmacological profiles and chemical behavior. As researchers continue to delve into its properties, N-(2-chloro-5-ethyl-phenyl)-3-(diethylamino)butanamide could very well become pivotal in future advancements in chemistry and medicine.

Synonyms
2'-Chloro-3-(diethylamino)-5'-ethylbutyranilide
736-20-9
BRN 2698824
beta-Diaethylamino-3-aethyl-6-chlor-butyranilid [German]
Butanamide, N-(2-chloro-5-ethylphenyl)-3-(diethylamino)-
BUTYRANILIDE, 2'-CHLORO-3-(DIETHYLAMINO)-5'-ETHYL-
beta-Diaethylamino-3-aethyl-6-chlor-butyranilid
DTXSID50994384
N-(2-Chloro-5-ethylphenyl)-3-(diethylamino)butanimidic acid