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Nilvadipine

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Identification
Molecular formula
C19H19ClN2O3
CAS number
75530-68-6
IUPAC name
N-(2-chloro-6-methyl-phenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide
State
State

At room temperature, Nilvadipine is typically a solid, presented as a powder form suitable for pharmaceutical manufacturing.

Melting point (Celsius)
106.00
Melting point (Kelvin)
379.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
384.83g/mol
Molar mass
384.8310g/mol
Density
1.3720g/cm3
Appearence

Nilvadipine is typically a yellow crystalline powder. It is not soluble in water but is soluble in organic solvents such as ethanol and acetone.

Comment on solubility

Solubility of N-(2-chloro-6-methyl-phenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide

The solubility of N-(2-chloro-6-methyl-phenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide can be influenced by several factors, as its chemical structure presents both hydrophobic and polar characteristics. Understanding solubility is key for applications in pharmaceuticals and chemical synthesis.

Key Factors Influencing Solubility:

  • Polarity: The compound's polar amide group can promote solubility in polar solvents, such as water and alcohols.
  • Hydrophobic Regions: The chloro and methyl substitutions on the aromatic ring contribute to hydrophobic interactions, possibly decreasing solubility in aqueous solutions.
  • Temperature: Increasing temperature often enhances solubility, making it a crucial factor during dissolution processes.
  • pH Level: The solubility may vary with changes in pH, particularly due to the carboxamide functional group which can participate in protonation and deprotonation reactions.

In conclusion, while the compound's solubility can be expected to be moderate, it will vary significantly based on the solvent environment and conditions. Always consider testing experimentally for precise solubility data, as theoretical predictions might not account for all intermolecular interactions.

Interesting facts

Discovering N-(2-chloro-6-methyl-phenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide

N-(2-chloro-6-methyl-phenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide, commonly known for its intricate molecular structure, offers a range of fascinating insights for both chemists and students alike. Here are some points that highlight its importance and unique characteristics:

  • Pharmaceutical Applications: This compound belongs to a class of compounds that can exhibit significant biological activity, making it a potential candidate in the field of drug development. Many pyridine derivatives are known for their role in medicinal chemistry.
  • Synthesis Challenges: The synthesis of N-(2-chloro-6-methyl-phenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide can present challenges, given its specialized functional groups. Understanding these challenges is crucial for chemists looking to innovatively design new pharmaceuticals.
  • Mechanistic Studies: This compound opens the door for exciting mechanistic studies. Research can explore how modifications in its structure affect biological activity, leading to the discovery of novel compounds with enhanced efficacy.
  • Versatile Chemical Framework: A feature of N-(2-chloro-6-methyl-phenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide is its versatile chemical framework. This allows for potential derivatization or modification, enabling applications across various fields including agrochemicals and biochemistry.

As chemistry students delve into the world of organic compounds, understanding the properties and potential applications of compounds like this can enrich their learning experience. In the words of a famed chemist, "The beauty of chemistry lies in its complexity and its ability to create change for the better." This compound embodies that ethos beautifully.

Synonyms
BRN 0410548
1,2,5,6-Tetrahydro-6'-chloro-1-methyl-o-nicotinotoluidide
23360-55-6
N-(1-Methyl-1,2,5,6-tetrahydronicotinoyl)-2-chloro-6-methylaniline
o-NICOTINOTOLUIDIDE, 1,2,5,6-TETRAHYDRO-6'-CHLORO-1-METHYL-
DTXSID50177918
RefChem:366498
DTXCID10100409