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2-Chloroacetanilide

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Identification
Molecular formula
C8H8ClNO
CAS number
95-76-1
IUPAC name
N-(2-chlorophenyl)acetamide
State
State

At room temperature, 2-Chloroacetanilide is in a solid state, typically maintaining a stable crystalline form under standard conditions.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
171.61g/mol
Molar mass
171.6110g/mol
Density
1.3680g/cm3
Appearence

2-Chloroacetanilide appears as a crystalline solid which may exhibit a white to off-white color. Its solid nature is indicative of its typical form at standard conditions, which includes room temperature and atmospheric pressure. The crystalline structure contributes to its distinctive solid state appearance.

Comment on solubility

Solubility of N-(2-chlorophenyl)acetamide

N-(2-chlorophenyl)acetamide, with the chemical formula C8H8ClNO, exhibits distinct solubility characteristics that are noteworthy for both industrial and laboratory contexts. Here’s what you should know:

  • Polarity: The presence of the chlorophenyl group introduces significant dimensionality and polarity to the molecule, influencing its interactions with solvents.
  • Solvent Affinity: N-(2-chlorophenyl)acetamide is generally soluble in organic solvents such as:
    • Acetone
    • EtOH (Ethanol)
    • DMSO (Dimethyl sulfoxide)
    • Chloroform
  • Water Solubility: However, its solubility in water is limited, reflective of its hydrophobic character due to the aromatic ring.
  • Concentration Factors: The solubility can vary with concentration, temperature, and the presence of other solutes.

In summary, N-(2-chlorophenyl)acetamide demonstrates a strong preference for organic solvents over aqueous ones, showcasing how its structure impacts its solubility behavior. Understanding these properties can be crucial for applications in various chemical processes and research methodologies.

Interesting facts

Interesting Facts about N-(2-chlorophenyl)acetamide

N-(2-chlorophenyl)acetamide, also known as 2-Chlorophenylacetamide, is a compound that offers intriguing insights into various fields of chemistry, particularly in pharmaceuticals and agrochemicals. Here are some fascinating aspects of this compound:

  • Pharmaceutical Significance: Compounds similar to N-(2-chlorophenyl)acetamide are often investigated for their potential therapeutic effects. They may act as intermediates in the synthesis of various drugs, highlighting their importance in drug development.
  • Structure-Activity Relationship: Understanding how the substitution of chlorine affects the compound's biological activity can lead to the creation of more effective and targeted drugs. This exploration into its structure-activity relationship (SAR) is a key area of research.
  • Synthesis: The synthesis of N-(2-chlorophenyl)acetamide involves straightforward organic reactions, making it a useful compound for students learning about amide formation, halogenation, and condensation reactions.
  • Applications in Agrochemistry: Similar compounds often find usage in the agrochemical sector as they can exhibit herbicidal or fungicidal properties, helping in the development of safer farming practices.
  • Research Potential: There has been ongoing research into derivatives of this compound, exploring modifications to enhance its efficacy or reduce side effects, showcasing the compound's versatility in scientific studies.

As a compound with both historical significance and modern applications, N-(2-chlorophenyl)acetamide exemplifies how chemical research continuously evolves to address contemporary challenges in health and agriculture. The journey of this compound illustrates the interconnectedness of various scientific disciplines and the ongoing quest for innovation.

Synonyms
2'-Chloroacetanilide
N-(2-Chlorophenyl)acetamide
O-CHLOROACETANILIDE
Acetamide, N-(2-chlorophenyl)-
2'-Chloro acetanilide
UNII-20C42PA69Y
HSDB 1408
20C42PA69Y
NSC-8455
EINECS 208-555-2
NSC 40562
NSC-40562
Acetic acid, amide, N-(2-chlorophenyl)-
ACETANILIDE, O-CHLORO-
DTXSID2060200
KNVQTRVKSOEHPU-UHFFFAOYSA-
2'Chloroacetanilide
Acetanilide, 2'chloro
N(2Chlorophenyl)acetamide
Acetamide, N(2chlorophenyl)
DTXCID1041390
Acetic acid, amide, N(2chlorophenyl)
ACETIC ACID, AMIDE, N(2-CHLOROPHENYL)-
inchi=1/c8h8clno/c1-6(11)10-8-5-3-2-4-7(8)9/h2-5h,1h3,(h,10,11)
knvqtrvksoehpu-uhfffaoysa-n
533-17-5
Acetanilide, 2'-chloro-
MFCD00045169
a-Chloroacetanilide
2?-CHLOROACETANILIDE
N-(2-chlorophenyl)-acetamide
SCHEMBL646296
N-(2-Chlorophenyl)acetamide #
CHEBI:35087
NSC8455
NSC40562
AC7922
STK067221
AKOS000492799
PS-5930
SY048591
DB-052295
C0621
CS-0084722
NS00032713
2 inverted exclamation mark -Chloroacetanilide
Q27116406