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Monomethine acridone

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Identification
Molecular formula
C19H13ClN2
CAS number
86376-48-1
IUPAC name
N-(2-chlorophenyl)acridin-9-amine
State
State

At room temperature, N-(2-chlorophenyl)acridin-9-amine is a solid compound.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
315.78g/mol
Molar mass
315.7770g/mol
Density
1.3590g/cm3
Appearence

N-(2-chlorophenyl)acridin-9-amine appears as a crystalline solid, typically yellow to brown in color. The compound may exhibit various shades depending on its form and purity.

Comment on solubility

Solubility of N-(2-chlorophenyl)acridin-9-amine

N-(2-chlorophenyl)acridin-9-amine exhibits particular solubility characteristics that are essential to understand for its applications. Generally, this compound shows moderate solubility in various organic solvents, while its solubility in water is quite limited. The presence of the 2-chlorophenyl group in the structure influences its interaction with solvents, leading to interesting solubility behavior.

Factors Affecting Solubility:

  • Polarity: The polar nature of the amine group contributes to its interaction with polar solvents, though the overall structure remains predominantly non-polar.
  • Hydrophobic Interactions: The acridine backbone is hydrophobic, which can reduce solubility in aqueous environments, making it less favorable in polar solvents.
  • Temperature: Generally, an increase in temperature can improve solubility in organic solvents, and this compound follows such trends.

As a rule of thumb, one can summarize that:

  • N-(2-chlorophenyl)acridin-9-amine is more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  • Its limited solubility in water may pose challenges for certain applications, making solvent selection crucial in practical scenarios.

In conclusion, understanding the solubility profile of N-(2-chlorophenyl)acridin-9-amine can significantly influence its usage in various chemical contexts, particularly in fields like pharmaceuticals and materials science.

Interesting facts

Interesting Facts about N-(2-Chlorophenyl)acridin-9-amine

N-(2-Chlorophenyl)acridin-9-amine is an intriguing compound that combines elements of both organic chemistry and medicinal chemistry. This compound features an acridine core, an aromatic heterocycle, known for its diverse biological activities. Here are some fascinating details about this compound:

  • Acridine Derivatives: The acridine moiety is often recognized for its role in a variety of biological applications, including anti-cancer and anti-viral properties. This makes N-(2-Chlorophenyl)acridin-9-amine a compound worth studying further in medicinal contexts.
  • Substituent Influence: The presence of the 2-chlorophenyl group plays a significant role in modulating the compound's reactivity and biological activity. The chlorine substituent can enhance the lipophilicity of the molecule, influencing its interaction with biological membranes.
  • Potential Applications: Research shows that acridine derivatives like this compound can be utilized in the development of new therapeutic agents, including those targeting DNA. Scientists are continually exploring their applications in treating diseases, particularly in oncology.
  • Research Interest: The unique structure of N-(2-Chlorophenyl)acridin-9-amine invites organic chemists to investigate its synthesis and reactions. Each study adds to our understanding of how structural variations can affect chemical behavior.
  • Structure-Activity Relationships: This compound opens avenues for extensive studies in structure-activity relationships (SAR). By examining how minor changes in structure impact biological activity, researchers can optimize existing compounds for better efficacy.

As stated by one researcher, "The potential hidden within acridine derivatives is a testament to the dynamic nature of chemical research." This compound exemplifies the intersection of creativity and scientific inquiry in the pursuit of new medicinal therapies.

In conclusion, N-(2-Chlorophenyl)acridin-9-amine stands as a valuable candidate in the field of chemical research, with significant implications for future studies and therapeutic developments.

Synonyms
N-(2-chlorophenyl)acridin-9-amine
CHEMBL48664
JWJNRFPYXGTVPU-UHFFFAOYSA-N
STL088554
AKOS001628615
N-(2-Chlorophenyl)-9-acridinamine #
Acridin-9-yl-(2-chloro-phenyl)-amine