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Lidocaine

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Identification
Molecular formula
C14H22N2O2
CAS number
137-58-6
IUPAC name
N-[2-(diethylamino)ethyl]-4-nitro-benzamide
State
State

At room temperature, lidocaine exists as a solid in its pure form but is frequently used as an aqueous solution for medical applications.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.29
Boiling point (Kelvin)
623.44
General information
Molecular weight
235.34g/mol
Molar mass
235.3440g/mol
Density
1.2000g/cm3
Appearence

Lidocaine is typically available as a white crystalline powder, which may appear slightly off-white due to impurities. When formulated into solutions, it is usually a clear, colorless liquid.

Comment on solubility

Solubility of N-[2-(diethylamino)ethyl]-4-nitro-benzamide

N-[2-(diethylamino)ethyl]-4-nitro-benzamide, a compound often utilized in pharmaceutical applications, exhibits specific solubility characteristics that are crucial for its function and effectiveness. The solubility of this compound can be influenced by various factors, including:

  • Temperature: Generally, an increase in temperature can enhance the solubility of solids and improve the dissolution rates.
  • pH Level: The pH of the solvent can significantly impact the solubility, particularly for compounds containing amine groups.
  • Presence of Solvents: N-[2-(diethylamino)ethyl]-4-nitro-benzamide is soluble in organic solvents such as ethanol and DMSO, but its solubility in water may be limited due to its hydrophobic characteristics.

In general, solvents that can interact with the nitrile and amine groups might facilitate solubility.


To summarize, it is essential to understand the solubility profile of N-[2-(diethylamino)ethyl]-4-nitro-benzamide for ensuring optimal formulation and application in various chemical processes. The ability to dissolve effectively can determine the compound's bioavailability and interaction with biological systems.

Interesting facts

Interesting Facts about N-[2-(diethylamino)ethyl]-4-nitro-benzamide

N-[2-(diethylamino)ethyl]-4-nitro-benzamide, commonly known as a compound in the field of medicinal chemistry, is notable for its potential applications in pharmacology and research. Here are some compelling insights about this compound:

  • Pharmacological Interest: This compound's structure indicates that it may exhibit unique biological activities, particularly due to the presence of the nitro group and the diethylamino moiety. This combination is significant in drug development as these groups can enhance solubility and bioactivity.
  • Mechanistic Studies: Scientists utilize derivatives of this compound in mechanistic studies to understand how certain drugs affect biological systems. The 4-nitro substituent can facilitate specific interactions at active sites of receptors or enzymes.
  • Research Tools: Compounds like N-[2-(diethylamino)ethyl]-4-nitro-benzamide are often used as tools in laboratory settings to investigate cellular responses and pharmacodynamics, offering insights into how modifications in chemical structure can alter biological function.
  • Structure-Activity Relationship (SAR): The structure of this compound makes it a candidate for SAR studies, where scientists explore how changes to the molecular structure affect the pharmacological activity, paving the way for the design of more effective drugs.
  • Potential Side Effects: As with many compounds in its class, understanding the safety profiles is crucial. Researchers often evaluate cytotoxicity and side effects associated with compounds like this, which has implications for medicinal use.

With ongoing research, N-[2-(diethylamino)ethyl]-4-nitro-benzamide continues to be a subject of interest, embodying the intricate relationship between organic chemistry and pharmacology. The exploration of such compounds is essential in advancing drug discovery and therapeutic applications. As scientists delve deeper, the potential of this compound may yield significant breakthroughs in medicine.

Synonyms
4-Nitroprocainamide
1664-52-4
Benzamide, N-[2-(diethylamino)ethyl]-4-nitro-
DTXSID40168097
Benzamide, N-(2-(diethylamino)ethyl)-4-nitro-
DTXCID6090588
N-[2-(diethylamino)ethyl]-4-nitrobenzamide
N-(2-(2-DIETHYLAMINO)ETHYL)-4-NITROBENZAMIDE
N-(2-(Diethylamino)ethyl)-4-nitrobenzamide
EV6KR53PBY
N-[2-(Diethylamino)ethyl](4-nitrophenyl)carboxamide
SCHEMBL3570124
CHEMBL3302168
STL070894
AKOS000503291
N-(2-diethylaminoethyl)-4-nitro-benzamide
4-nitro-N-[2-(diethylamino)ethyl]benzamide
N-(2-(diethylamino)-ethyl)-4-nitrobenzamide