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Propoxyphene

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Identification
Molecular formula
C22H29NO2
CAS number
469-62-5
IUPAC name
N-[2-(diethylamino)ethyl]-N-(3-methoxyphenyl)-2-(4-propoxyphenoxy)acetamide
State
State

At room temperature, Propoxyphene is in a solid state. It is usually encountered as its hydrochloride salt in medical or chemical settings, which enhances its aqueous solubility compared to the base form.

Melting point (Celsius)
40.00
Melting point (Kelvin)
313.15
Boiling point (Celsius)
607.00
Boiling point (Kelvin)
880.15
General information
Molecular weight
339.48g/mol
Molar mass
339.4680g/mol
Density
1.0830g/cm3
Appearence

Propoxyphene appears as a white crystalline solid. It is typically handled as a hydrochloride salt for pharmaceutical use, where it takes the form of a powder that is often formulated into capsules or tablets. The crystalline form is characterized by its fine texture and opacity.

Comment on solubility

Solubility of N-[2-(diethylamino)ethyl]-N-(3-methoxyphenyl)-2-(4-propoxyphenoxy)acetamide

This compound, with its complex structure, presents an intriguing case in terms of solubility characteristics. Understanding its solubility is essential as it can greatly influence its behavior in various applications. Here are some insights into its solubility:

  • Polar and Non-polar Regions: The presence of both polar functional groups, such as the diethylamino and methoxy groups, and non-polar phenyl rings suggests that the compound may exhibit amphiphilic properties, allowing it to potentially dissolve in both polar and non-polar solvents.
  • Solvent Compatibility: It is likely to show good solubility in organic solvents like ethanol, acetone, and dimethyl sulfoxide (DMSO), while its solubility in water may be limited due to the bulkiness of the propoxy and phenoxy groups.
  • Temperature Influence: As a general rule, increasing temperature often increases solubility. Hence, elevated temperatures may enhance the solubility of this compound in suitable solvents.
  • pH Sensitivity: The diethylamino group may affect solubility in aqueous solutions by altering its protonation state, indicating a potential pH dependence in its solubility profile.

In conclusion, while this compound is expected to have some degree of solubility in various media, the specific conditions such as pH and temperature will play a vital role in its overall solubility behavior. Further experimental studies would be invaluable to elucidate its solubility in detail.

Interesting facts

Interesting Facts about N-[2-(diethylamino)ethyl]-N-(3-methoxyphenyl)-2-(4-propoxyphenoxy)acetamide

N-[2-(diethylamino)ethyl]-N-(3-methoxyphenyl)-2-(4-propoxyphenoxy)acetamide is a notable compound in medicinal chemistry, particularly for its potential therapeutic applications. Here are some intriguing aspects of this compound:

  • Pharmaceutical Relevance: This compound is studied for its potential role as a pharmacological agent, often investigated for its effects in treating various conditions, including pain and related disorders.
  • Complex Structure: The intricate structure features multiple functional groups, including an acetamide moiety and a methoxy-substituted aromatic ring. Such complexity can lead to unique interactions with biological targets.
  • Multifunctional Design: The presence of both diethylamino and propoxyphenoxy groups indicates the compound's potential for multifunctionality, which can enhance its activity and selectivity towards specific receptors or enzymes.
  • Research Insights: Chemical derivatives of compounds like this one contribute significantly to the understanding of drug design. Researchers often modify the structure to predict how these changes might impact biological activity.
  • Future Directions: Ongoing studies aim to elucidate the mechanism of action of this compound, seeking to improve efficacy and reduce side effects. The exploration of its structure-activity relationships (SAR) remains a key focus area.

In summary, N-[2-(diethylamino)ethyl]-N-(3-methoxyphenyl)-2-(4-propoxyphenoxy)acetamide exemplifies the intersection of chemistry and pharmacology, embodying the potential for innovative therapies driven by carefully curated chemical properties. As with many compounds derived from organic synthesis, its journey from the laboratory to clinical applications captivates scientists and students alike, illustrating the profound impact of chemical research on health and medicine.