Skip to main content

Loperamide

ADVERTISEMENT
Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
N-[2-(dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenyl-acetamide
State
State
Solid at room temperature.
Melting point (Celsius)
218.00
Melting point (Kelvin)
491.20
Boiling point (Celsius)
502.40
Boiling point (Kelvin)
775.60
General information
Molecular weight
477.03g/mol
Molar mass
477.0960g/mol
Density
1.0600g/cm3
Appearence

Loperamide is a white to off-white powder that is crystalline in nature. It does not have any significant odor.

Comment on solubility

Solubility of N-[2-(dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenyl-acetamide

N-[2-(dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenyl-acetamide, a compound with a rather complex structure, displays interesting solubility characteristics influenced by its molecular constituents. As with many organic compounds, solubility can vary significantly based on several factors:

  • Polarity: This compound contains both polar and nonpolar groups, suggesting that it may exhibit a moderate level of solubility in polar solvents such as water, although the presence of large hydrophobic groups could inhibit this.
  • Hydrophobic Interactions: The bulky diphenyl and ethylbutoxy groups may lead to greater solubility in organic solvents like methanol, ethanol, or chloroform, where hydrophobic interactions facilitate solvation.
  • Temperature Effects: Generally, increasing temperature can enhance the solubility of many compounds; thus, heating the solvent may improve the solubility of this acetamide in organic solvents.
  • Concentration: In practical applications or formulations, the concentration will also greatly affect solubility, with increased concentration potentially promoting precipitation in less favorable solvents.

In essence, while the solubility profile of this compound may be intriguing, it is advised to conduct empirical solubility tests in various solvents to obtain precise data. As the old saying goes, "The proof of the pudding is in the eating." Thus, the best way to ascertain its solubility is through experimentation!

Interesting facts

Interesting Facts about N-[2-(dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenyl-acetamide

N-[2-(dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenyl-acetamide, often referred to as a member of the amide family, boasts a rich array of intriguing properties and applications. Here are some noteworthy points about this remarkable compound:

  • Structural Complexity: This compound features multiple functional groups, including amides and alkoxy chains, which contribute to its unique chemical behavior and potential interactions in various environments.
  • Pharmaceutical Applications: Compounds of this type are often investigated for their biological activity. They may exhibit characteristics as analgesics or anti-inflammatory agents, making them valuable in medical research.
  • Dimethylamino Group: The presence of the dimethylamino moiety provides an intriguing layer of reactivity, potentially enhancing the compound's interaction with target receptors in biological systems.
  • Alkyl Chain Influence: The ethylbutoxy substituent can influence lipid solubility, which may impact the pharmacokinetics of the compound, affecting absorption and distribution in the body.
  • Research Potential: The intricate structure opens avenues for future research in medicinal chemistry, particularly in designing derivatives that could enhance efficacy or reduce side effects.

As emphasized by many researchers in the field, "Understanding the structure-activity relationship in compounds like N-[2-(dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenyl-acetamide is crucial for the development of novel therapeutic agents." This compound exemplifies the fine balance of complexity and potential utility that makes organic compounds so fascinating to study.