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N-(2-fluoro-4-phenylphenyl)acetamide

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Identification
Molecular formula
C14H12FNO
CAS number
285272-73-1
IUPAC name
N-(2-fluoro-4-phenyl-phenyl)acetamide
State
State

At room temperature, N-(2-fluoro-4-phenylphenyl)acetamide is typically in a solid state.

Melting point (Celsius)
132.00
Melting point (Kelvin)
405.15
Boiling point (Celsius)
378.00
Boiling point (Kelvin)
651.15
General information
Molecular weight
229.24g/mol
Molar mass
229.2440g/mol
Density
1.1890g/cm3
Appearence

N-(2-fluoro-4-phenylphenyl)acetamide appears as a white to off-white crystalline solid.

Comment on solubility

Solubility of N-(2-fluoro-4-phenyl-phenyl)acetamide

N-(2-fluoro-4-phenyl-phenyl)acetamide exhibits selective solubility characteristics that can be influenced by various factors:

  • Polar vs. Non-Polar Solvents: This compound is expected to be more soluble in polar organic solvents due to the presence of an acetamide functionality which can engage in hydrogen bonding.
  • Temperature Dependence: Solubility may increase with temperature, which is typical for many organic compounds, enhancing the kinetic energy of molecules for better dissolution.
  • pH Sensitivity: The ionization state of the acetamide may vary with the pH of the solvent, potentially increasing solubility in basic solutions.

In conclusion, N-(2-fluoro-4-phenyl-phenyl)acetamide's solubility profile can be summarized as follows:

  1. Good solubility in polar solvents
  2. Increased solubility with rising temperatures
  3. Variable solubility with pH changes

Understanding these solubility behaviors is crucial in applications such as formulation development and pharmaceutical chemistry.

Interesting facts

Interesting Facts About N-(2-fluoro-4-phenyl-phenyl)acetamide

N-(2-fluoro-4-phenyl-phenyl)acetamide is an intriguing compound in the realm of organic chemistry. It falls within the category of amides, which are known for their diverse applications and vital roles in the synthesis of pharmaceuticals and agrochemicals.

Key Characteristics

  • Structural Significance: This compound includes a fluorine atom which significantly influences its chemical reactivity and physical properties. Fluorine is known for enhancing the bioactivity of organic molecules.
  • Pharmaceutical Potential: Compounds that contain phenyl groups are often explored in drug design. The unique substitution of the 2-fluoro and 4-phenyl groups may yield novel therapeutic agents, making this compound of high interest in medicinal chemistry.
  • Mechanism of Action: The presence of the acetamide functional group is essential in biological systems, often acting as a bioisostere to replace more traditional functional groups, which can help to improve the solubility and bioavailability of pharmaceuticals.

Research Insights

Recent studies have indicated that amides, particularly those with additional aromatic systems, can exhibit unique interactions with biological targets. Research into N-(2-fluoro-4-phenyl-phenyl)acetamide may uncover:

  • Enhanced pharmacological properties compared to simpler amide compounds.
  • Potential applications in the development of anti-cancer agents or treatments for neurodegenerative diseases, due to the structural features that allow for selective targeting.

Conclusion

As a fascinating compound, N-(2-fluoro-4-phenyl-phenyl)acetamide represents a compelling area of study for chemists interested in the synthesis of new materials and the exploration of their practical applications. Its structural components provide numerous avenues for research, allowing scientists to innovate and potentially discover life-altering therapies.

Synonyms
725-04-2
ACETANILIDE, 2'-FLUORO-4'-PHENYL-
3-Fluoro-4-acetylaminobiphenyl
2'-Fluoro-4'-phenylacetanilide
Acetamide,N-(3-fluoro[1,1'-biphenyl]-4-yl)-
DTXSID80222804