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Furoylaminopyridine

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Identification
Molecular formula
C11H9N3O2
CAS number
61872-43-1
IUPAC name
N-(2-furylmethyleneamino)pyridine-4-carboxamide
State
State

At room temperature, N-(2-furylmethyleneamino)pyridine-4-carboxamide exists as a solid. It is stable under standard laboratory conditions and should be handled with standard precautions.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.00
Boiling point (Celsius)
388.00
Boiling point (Kelvin)
661.00
General information
Molecular weight
200.20g/mol
Molar mass
200.2000g/mol
Density
1.3550g/cm3
Appearence

The compound N-(2-furylmethyleneamino)pyridine-4-carboxamide appears as a crystalline solid and is often characterized by its yellow to orange color. This can vary slightly depending on the purity and specific conditions of synthesis.

Comment on solubility

Solubility of N-(2-furylmethyleneamino)pyridine-4-carboxamide

N-(2-furylmethyleneamino)pyridine-4-carboxamide is a compound that exhibits unique solubility characteristics influenced by its structural components. Understanding its solubility profile is essential for applications in pharmaceuticals and other fields. Here are some key points regarding its solubility:

  • Polar and Nonpolar Interactions: The presence of both the pyridine ring and the furan moiety suggests that the compound may display both polar and nonpolar characteristics, impacting its solubility.
  • Solvent Compatibility: It is likely to be soluble in polar solvents such as water and ethanol, while having limited solubility in nonpolar solvents like hexane due to its polar functional groups.
  • pH Dependence: The solubility can be pH-dependent. Increasing acidity (lower pH) may enhance solubility by protonating the nitrogen in the carboxamide group, making it more hydrophilic.
  • Crystallization Potential: Its molecular structure may promote crystallization under certain conditions, potentially leading to the formation of solvates with specific solvents.

In summary, the solubility of N-(2-furylmethyleneamino)pyridine-4-carboxamide is influenced by factors such as solvent type, pH, and intermolecular interactions. This makes the compound a subject of interest in solubility studies, particularly for applications in drug formulation and delivery.

Interesting facts

Interesting Facts about N-(2-furylmethyleneamino)pyridine-4-carboxamide

N-(2-furylmethyleneamino)pyridine-4-carboxamide is a fascinating compound that belongs to the family of heterocyclic compounds. It has garnered interest in the field of medicinal chemistry due to its potential bioactivity and unique structural features.

Key Characteristics

  • Heterocyclic Structure: This compound features both a pyridine ring and a furan moiety, which contribute to its diverse chemical behavior and biological activity.
  • Potential Pharmacological Activity: Compounds like this have been investigated for their antitumor, anti-inflammatory, and antimicrobial properties, making them valuable in drug development.
  • Versatility: The presence of various functional groups allows for modification and optimization of the compound to enhance its efficacy and selectivity toward specific biological targets.

Applications

The interest in N-(2-furylmethyleneamino)pyridine-4-carboxamide is not limited to theoretical studies; it extends into practical applications:

  • Drug Design: Due to its complex structure, it serves as a scaffold in the design of new therapeutic agents.
  • Research Tool: Used in the study of enzyme inhibition and receptor binding, contributing to a greater understanding of biochemical pathways.

Scientific Significance

Beyond its practical applications, the study of compounds like N-(2-furylmethyleneamino)pyridine-4-carboxamide reveals important insights into:

  • The interactions between various chemical species in biological systems.
  • How small structural changes can lead to significant differences in biological activity.

As noted by chemists, "Understanding the relationship between structure and function is vital for the advancement of medicinal chemistry." This encapsulates the essence of studying compounds like N-(2-furylmethyleneamino)pyridine-4-carboxamide, which continues to inspire both emerging chemists and seasoned researchers alike.

Synonyms
N-(furan-2-ylmethylideneamino)pyridine-4-carboxamide
2-furaldehyde isonicotinoylhydrazone
CBDivE_001641
SCHEMBL6055366
DTXSID001305097
HMS2445H17
AKOS034405113
N'-[(furan-2-yl)methylidene]pyridine-4-carbohydrazide