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Tramadol

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Identification
Molecular formula
C16H25NO2
CAS number
27203-92-5
IUPAC name
N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide
State
State

Tramadol is typically in a solid state at room temperature. It is not volatile and is stable under normal conditions. Tramadol is regularly used in its solid form in pharmaceutical preparations.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
378.90
Boiling point (Kelvin)
652.05
General information
Molecular weight
263.38g/mol
Molar mass
263.3810g/mol
Density
1.4294g/cm3
Appearence

Tramadol appears as a white to off-white crystalline powder. It is commonly found in tablet or capsule form for pharmaceutical use. The compound is typically odorless and has a bitter taste.

Comment on solubility

Solubility of N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide is a unique compound with interesting solubility characteristics. The solubility of this compound can be influenced by several factors:

  • Polarity: Due to the presence of a hydroxyl group, the compound exhibits polar characteristics, which can enhance its solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl group enables the formation of hydrogen bonds, further promoting solubility in polar solvents.
  • Molecular Interactions: Its structure allows it to engage in various molecular interactions, which can affect solubility in non-polar solvents.
  • Concentration and Temperature: Like many compounds, solubility can vary with changes in concentration and temperature, and higher temperatures might increase solubility.

Overall, it can be concluded that N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide is more likely to be soluble in polar solvents while showing limited solubility in non-polar environments. Further experimental data would provide a more detailed understanding of its solubility behavior.

Interesting facts

Interesting Facts About N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide, often referred to as a member of the acetamide family, is a compound that showcases intriguing properties and applications in the field of chemistry. Here are some fascinating insights:

  • Pharmacological Significance: This compound is known to exhibit a range of biological activities. It has been studied for its potential in drug development, particularly for its effects on the central nervous system.
  • Dual Functional Group: The presence of both hydroxy and acetamide functional groups allows for diverse reactivity. This versatility makes it a valuable building block in synthetic chemistry.
  • Structure-Activity Relationship (SAR): Investigations into its structure have revealed that slight modifications can lead to significant changes in biological activity. This property is critical for medicinal chemistry, as it aids in the design of more effective pharmaceuticals.
  • Natural Product Inspiration: Compounds with similar structures are often inspired by natural products, which are frequently a source of medicinal chemicals. Understanding the interactions of this compound with biological systems contributes to the broader knowledge of bioactive molecules.
  • Research Applications: It's being explored in various fields, including biochemistry and materials science, as a potential agent for novel applications in drug delivery and formulation.

In summary, N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide is not only a compound of interest due to its chemical structure but also for its potential implications in pharmacology and synthetic chemistry. As with many compounds in the chemical sciences, continued research may unlock new possibilities for its use.

Synonyms
N-(1-hydroxy-1-phenylpropan-2-yl)-N-methylacetamide
rac N-Acetyl Ephedrine
N-(beta-Hydroxy-alpha-methylphenethyl)-N-methylacetamide
rac N-Acetyl-Pseudoephedrine
Benzyl alcohol, alpha-(1-(N-methylacetamido)ethyl)-
Phenethylamine, N-acetyl-N,alpha-dimethyl-beta-hydroxy-
SCHEMBL4649609
DTXSID20936913
N-(beta-hydroxy-alpha-methylphenethyl)-N-methyl-acetamide
5878-95-5
DB-352410
N-acetyl-N-methyl-2-amino-1-phenylpropan-1-ol
Benzyl alcohol, .alpha.-(1-(N-methylacetamido)ethyl)-
N-(2-Hydroxy-1-methyl-2-phenylethyl)-N-methylacetamide #
Phenethylamine, N-acetyl-N,.alpha.-dimethyl-.beta.-hydroxy-