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Naphthylhydroxymethyl Pyridine Carboxamide

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Identification
Molecular formula
C18H13N3O2
CAS number
123456-78-9
IUPAC name
N-[(2-hydroxy-1-naphthyl)methyleneamino]pyridine-4-carboxamide
State
State

At room temperature, this compound is typically found in a solid state.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
504.00
Boiling point (Kelvin)
777.15
General information
Molecular weight
280.31g/mol
Molar mass
280.3060g/mol
Density
1.4528g/cm3
Appearence

The compound appears as a yellow-orange crystalline solid, reflecting its conjugated system which can absorb visible light.

Comment on solubility

Solubility Insights

The compound N-[(2-hydroxy-1-naphthyl)methyleneamino]pyridine-4-carboxamide (C18H13N3O2) showcases interesting solubility characteristics relevant to its chemical structure and functional groups. Understanding the solubility of this compound can be viewed through various perspectives:

  • Polarity: The presence of hydroxyl (-OH) and amine (-NH2) groups may lead to increased polarity, which can enhance solubility in polar solvents such as water.
  • Hydrogen bonding: The ability to form hydrogen bonds due to the hydroxyl and amide functionalities can significantly impact solubility. Strong hydrogen bonding interactions can lead to greater dissolution in appropriate solvents.
  • Solvent compatibility: This compound may show varying solubility in different solvents; it is likely to be more soluble in organic solvents (e.g., ethanol or dimethyl sulfoxide) compared to non-polar solvents.
  • Temperature effects: As with many organic compounds, solubility may increase with temperature, allowing for better dissolution properties at elevated temperatures.
  • Salt formation: The actions of counter-ions might be beneficial; protonating the amine group may enhance solubility through salt formation.

In summary, while specific quantitative solubility data may be limited, the structural attributes of N-[(2-hydroxy-1-naphthyl)methyleneamino]pyridine-4-carboxamide suggest that it is likely to exhibit appreciable solubility in polar solvents and moderate solubility in organic counterparts. Exploring practical solubility in laboratory settings can provide further insights.

Interesting facts

Interesting Facts about N-[(2-hydroxy-1-naphthyl)methyleneamino]pyridine-4-carboxamide

N-[(2-hydroxy-1-naphthyl)methyleneamino]pyridine-4-carboxamide is a fascinating compound with several unique attributes and potential applications in various fields. Here are some interesting aspects to consider:

  • Chemical Structure: This compound features a naphthalene moiety, a heterocyclic pyridine, and an amino group, showcasing its potential versatility in forming interactions with biological systems.
  • Biological Relevance: Compounds that include naphthyl and pyridine groups have been studied for their biological activities, including antibacterial and anticancer properties. They may inhibit specific enzymes or interact with cellular receptors, providing avenues for medicinal chemistry.
  • Research Applications: Due to its complex structure, this compound can serve as a valuable scaffold for the synthesis of various derivatives, which could be screened for pharmaceutical applications. Scientists continue to explore these derivatives to improve efficacy and reduce toxicity.
  • Synthetic Challenges: The synthesis of such compounds often involves intricate multi-step reactions, demonstrating the importance of organic chemistry techniques, such as Michael additions or condensation reactions.
  • Environmental Impact: The use of compounds with aromatic rings, like this one, raises questions about their environmental persistence and potential bioaccumulation. Understanding these factors is critical in the context of safety and regulations associated with chemical use.

As noted by prominent chemists, "The beauty of organic chemistry lies in the ability to manipulate molecules into forms that can have profound effects on health, environment, and technology." This compound exemplifies that beauty through its intricate structure and potential!

In summary, N-[(2-hydroxy-1-naphthyl)methyleneamino]pyridine-4-carboxamide is more than just a chemical formula; it represents a potential key player in drug development and biological research. The ongoing exploration of its characteristics will likely reveal even more about its significance in science.

Synonyms
796-42-9
AS 8351
AS8351
AS-8351
MLS002702858
NSC51355
2- HYDROXY-1-NAPHTHALDEHYDE-ISONICOTINOYLHYDRAZONE
CBDivE_006818
N'-[(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide
CHEMBL1698529
N-[(E)-(2-Hydroxynaphthalen-1-yl)methylideneamino]pyridine-4-carboxamide
AKOS016868139
NCI60_004242
PD064915
PD087472
SMR001495738
A3339
2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone