Sulfasalazine | Solubility of Things

Identification

Molecular formula

C₁₈H₁₄N₄O₅S

CAS number

599-79-1

IUPAC name

N-[2-hydroxy-3-(2-pyridylsulfonylamino)propyl]-4-methyl-2-(3-phenylphenyl)pentanamide

State

At room temperature, sulfasalazine is a solid. It typically exists in crystalline form, contributing to its characteristic powdery appearance.

Melting point (Celsius)

245.00

Melting point (Kelvin)

518.15

Boiling point (Celsius)

775.00

Boiling point (Kelvin)

1 048.15

General information

Molecular weight

398.39g/mol

Molar mass

398.4120g/mol

Density

1.7210g/cm³

Appearence

Sulfasalazine appears as a yellow to brownish powder with no distinctive smell. The compound is sparingly soluble in water, lending a slightly granular texture when observed. The presence of its chromophore gives it a characteristic yellowish tint that differentiates it from other sulfa-based drugs.

Comment on solubility

Solubility of N-[2-hydroxy-3-(2-pyridylsulfonylamino)propyl]-4-methyl-2-(3-phenylphenyl)pentanamide

The solubility characteristics of the compound N-[2-hydroxy-3-(2-pyridylsulfonylamino)propyl]-4-methyl-2-(3-phenylphenyl)pentanamide (C₁₈H₁₄N₄O₅S) can be intriguing, as they may reveal important insights regarding its application and behavior in various environments.

Key Considerations for Solubility

Polarity: The presence of various functional groups, particularly the hydroxy group and sulfonamide, suggests that this compound may exhibit polar characteristics, influencing its solubility in polar solvents such as water.
Hydrogen Bonding: The ability to form hydrogen bonds due to the hydroxy group could contribute to enhanced solubility in polar solvents, while also affecting interactions with other solutes.
Hydrophobic Regions: The pentanamide and phenyl groups introduce hydrophobic characteristics, likely resulting in decreased solubility in purely aqueous environments.
Solvent Compatibility: It is anticipated that this compound may show variable solubility depending on the solvent used, with potential higher solubility in organic solvents compared to water.

In summary, the solubility of N-[2-hydroxy-3-(2-pyridylsulfonylamino)propyl]-4-methyl-2-(3-phenylphenyl)pentanamide is influenced by its complex structure, balancing polar and non-polar interactions. Further empirical studies would provide a clearer picture of its solubility profile in different solvents.

Interesting facts

Interesting Facts about N-[2-hydroxy-3-(2-pyridylsulfonylamino)propyl]-4-methyl-2-(3-phenylphenyl)pentanamide

N-[2-hydroxy-3-(2-pyridylsulfonylamino)propyl]-4-methyl-2-(3-phenylphenyl)pentanamide, often referred to as a complex organic molecule, showcases the fascinating world of bioactive compounds. Here are some compelling aspects to note:

Bioactivity Potential: This compound is of interest due to its potential interactions with biological systems, making it a candidate for drug development, particularly in targeting specific diseases or conditions.
Structural Diversity: The presence of both aromatic and aliphatic structures provides unique chemical properties, allowing for varied interactions in biological reactions.
Functional Groups: The molecule features important functional groups, such as the sulfonamide and hydroxyl functionalities, which play crucial roles in determining its reactivity and interaction with biomolecules.
Pharmacophore Exploration: It serves as a promising scaffold for pharmacophore studies, helping researchers understand how certain structural elements contribute to biological activity.
Research Applications: This compound is often used in medicinal chemistry research, opening avenues for the synthesis of derivatives that may enhance its efficacy or reduce side effects.

As a fascinating example of organic synthesis and its implications in drug discovery, N-[2-hydroxy-3-(2-pyridylsulfonylamino)propyl]-4-methyl-2-(3-phenylphenyl)pentanamide exemplifies how intricate molecular designs can lead to significant advancements in pharmaceutical sciences. In the words of a leading chemist, "The future of medicine lies in understanding and manipulating the molecules that define life."

Synonyms

PD039822