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Tamsulosin

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Identification
Molecular formula
C20H28N2O5S
CAS number
106133-20-4
IUPAC name
N-[2-hydroxy-5-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenyl]methanesulfonamide
State
State

At room temperature, tamsulosin is in a solid state.

Melting point (Celsius)
100.00
Melting point (Kelvin)
373.15
Boiling point (Celsius)
552.00
Boiling point (Kelvin)
825.15
General information
Molecular weight
408.54g/mol
Molar mass
408.5410g/mol
Density
1.1406g/cm3
Appearence

Tamsulosin is a white or almost white crystalline powder.

Comment on solubility

Solubility of N-[2-hydroxy-5-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenyl]methanesulfonamide

The solubility of the compound N-[2-hydroxy-5-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenyl]methanesulfonamide can be influenced by several factors due to its complex structure. Generally, the solubility characteristics can be summarized as follows:

  • Polarity: The presence of hydroxyl (-OH) groups typically enhances water solubility due to hydrogen bonding interactions.
  • Hydrophobic Regions: The phenyl and ethyl groups can hinder solubility in polar solvents like water, leading to increased lipophilicity.
  • Functional Groups: The methanesulfonamide moiety contributes to both aqueous solubility and potential interactions with biological targets.

Overall, the solubility of this compound can be expected to be:

  1. Moderate in aqueous environments, especially due to the sulfonamide's ability to engage in hydrogen bonding.
  2. Higher in organic solvents, where the hydrophobic character can be more readily accommodated.

In conclusion, the solubility profile of N-[2-hydroxy-5-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenyl]methanesulfonamide illustrates a balance between polar and non-polar characteristics, leading to a nuanced behavior in different solvents. This balance dictates how the compound may perform in various applications, emphasizing the importance of solubility in its functionality.

Interesting facts

Interesting Facts about N-[2-hydroxy-5-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenyl]methanesulfonamide

N-[2-hydroxy-5-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenyl]methanesulfonamide, commonly referred to in fields related to medicinal chemistry, presents itself as an intriguing compound with various significant aspects:

  • Pharmacological Relevance: This compound is often researched for its potential applications in pharmacology, specifically in the design of drugs that target specific biochemical pathways. Its sulfonamide group is well-known for its antibacterial properties, making it an important structure in medicinal chemistry.
  • Sulfamoyl Moiety: The presence of a methanesulfonamide group is notable as it is a structural feature found in a variety of therapeutics. Sulfamides have been explored for their ability to inhibit enzymes and receptors, which can be vital for treating various diseases.
  • Unique Substituents: The compound’s structure boasts unique substituents, such as the phenyl and hydroxy groups, that contribute to its biological activity. These functional groups can enhance the compound's ability to interact with biological macromolecules, facilitating drug design.
  • Studies and Applications: Ongoing research into this compound includes evaluating its efficacy and safety profiles as potential pharmacological agents. Scientists are particularly interested in how variations in the molecular structure can influence the compound's activity.
  • Analytical Techniques: Due to its complexity, researchers often employ advanced analytical techniques such as NMR spectroscopy and mass spectrometry to elucidate the compound's structure and confirm its purity during synthesis.

In conclusion, the study of N-[2-hydroxy-5-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenyl]methanesulfonamide is significant for understanding the roles of sulfonamides in pharmacology. It exemplifies how subtle changes in molecular architecture can lead to vastly different biochemical properties, serving as a great case study in medicinal chemistry.

Synonyms
SCHEMBL11797487