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Timolol

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Identification
Molecular formula
C13H24N4O3S
CAS number
26839-75-8
IUPAC name
N-[2-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propyl]phenyl]methanesulfonamide
State
State

Timolol is typically in a solid state at room temperature, appearing as a crystalline powder. It is used in different forms, including tablets and eye drops, the latter of which is a liquid formulation.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
498.15
Boiling point (Kelvin)
771.30
General information
Molecular weight
432.54g/mol
Molar mass
432.5420g/mol
Density
1.3000g/cm3
Appearence

Timolol typically appears as a white, crystalline powder. It is odorless or nearly odorless, which makes it suitable for pharmaceutical formulations, especially in its ophthalmic application.

Comment on solubility

Solubility of N-[2-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propyl]phenyl]methanesulfonamide

The solubility characteristics of N-[2-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propyl]phenyl]methanesulfonamide are intriguing due to its complex molecular structure. To better understand its solubility, we can consider several factors that influence this property:

  • Polarity: The presence of multiple hydroxyl groups contributes to its polarity, enhancing solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with both itself and surrounding molecules increases solvation possibilities.
  • Alkyl Chain Effects: The 4-methoxyphenyl group and ethylamino chain may introduce hydrophobic characteristics that can affect solubility in non-polar solvents.

In general, compounds of this nature tend to exhibit solubility in both aqueous and organic solvents, but the extent may vary considerably based on the solvent's properties. As reported in various studies, it is advisable to test solubility empirically, particularly when formulating formulations or considering applications in pharmaceutical contexts.

In conclusion, solubility plays a crucial role in understanding the behavior of N-[2-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propyl]phenyl]methanesulfonamide. Factors like polarity, hydrogen bonding, and hydrophobic interactions all interact to dictate how this compound will behave in different solvent environments.

Interesting facts

Interesting Facts about N-[2-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propyl]phenyl]methanesulfonamide

N-[2-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propyl]phenyl]methanesulfonamide, often abbreviated for convenience, is a fascinating compound with intriguing chemical properties and applications. Below are some noteworthy aspects:

  • Pharmaceutical Relevance: This compound is primarily recognized for its role in medicinal chemistry, especially as a potential drug candidate. It illustrates the complexity of designing molecules that can selectively inhibit biological targets.
  • Sulfonamide Backbone: The presence of the sulfonamide group contributes to the compound's effectiveness and solubility characteristics. Sulfonamides have been widely studied for their antibiotic properties, paving the way for various therapeutic applications.
  • Hydroxyl Groups: The compound features multiple hydroxyl groups, which play a crucial role in hydrogen bonding and could affect the bioavailability and interaction with biological macromolecules.
  • Structure-Activity Relationship (SAR): Understanding how specific structural modifications impact the activity of this compound is essential for medicinal chemists. Its design reflects classic SAR principles, which are vital in drug development.

Research surrounding this compound is ongoing, focusing on:

  1. Enhancing its efficacy and specificity against target diseases.
  2. Investigating its mechanism of action at the molecular level.
  3. Exploring potential side effects and optimizing formulation strategies.

As stated by many researchers in the field, "The path from chemical synthesis to therapeutic application is often as intricate as the molecules themselves." This compound exemplifies the synthesis journey of many modern pharmaceuticals, showcasing how complex configurations can lead to functional and effective drugs.

In conclusion, N-[2-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propyl]phenyl]methanesulfonamide is not just a compound of interest due to its chemical structure but also highlights the essential principles of drug discovery and development.

Synonyms
MESUPRINE
Mesuprine [INN]
Mesuprina
Mesuprinum
7541-30-2
Mesuprinum [INN-Latin]
Mesuprina [INN-Spanish]
UNII-MEO9P8EX05
MEO9P8EX05
Mesuprinum (INN-Latin)
Mesuprina (INN-Spanish)
Methanesulfonamide, N-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)ethyl)amino)propyl)phenyl)-
Methanesulfonanilide, 2'-hydroxy-5'-(1-hydroxy-2-((p-methoxyphenethyl)amino)propyl)-
N-[2-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propyl]phenyl]methanesulfonamide
Mesurpine
SCHEMBL248535
CHEMBL3990805
DTXSID60864089
NSC284706
Q27283974
N-(2-Hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)ethyl)amino)propyl)phenyl)-methanesulfonamide