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Timolol

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Identification
Molecular formula
C13H24N4O3S
CAS number
26839-75-8
IUPAC name
N-[2-hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide
State
State
At room temperature, timolol is a solid.
Melting point (Celsius)
202.00
Melting point (Kelvin)
475.15
Boiling point (Celsius)
259.00
Boiling point (Kelvin)
532.15
General information
Molecular weight
316.43g/mol
Molar mass
316.4250g/mol
Density
1.3000g/cm3
Appearence

Timolol is generally found as a white to off-white powder. It is odorless and frequently exists in a crystalline form.

Comment on solubility

Solubility of N-[2-hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide

N-[2-hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide, often referred to as a sulfonamide derivative, exhibits interesting solubility properties that are influenced by its chemical structure. Understanding its solubility is crucial for its application in pharmaceuticals and other fields.

Key Points on Solubility:

  • Polarity: The presence of hydroxyl groups and sulfonamide functionality enhances the overall polarity of the compound, which generally favors solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules contributes significantly to its solubility. This characteristic is pivotal in determining how the compound interacts in biological systems.
  • Solvent Dependence: Solubility may vary considerably depending on the solvent used; for instance, it is more likely to be soluble in ethanol and dimethyl sulfoxide (DMSO), which are polar aprotic solvents.
  • Temperature Effects: As with many chemical compounds, an increase in temperature could enhance solubility, making it an important factor to consider during formulation.

In summary, the solubility behavior of N-[2-hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide is influenced by its structural attributes, which can lead to various implications in its practical use. Thorough comprehension of these solubility traits aids scientists and researchers in predicting how this compound will perform in different environments.

Interesting facts

Exploring N-[2-hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide

N-[2-hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide, often referred to in the scientific community as a potential therapeutic agent, showcases a fascinating structure with remarkable properties. Here are some intriguing aspects of this compound:

  • Pharmacological Relevance: This compound has garnered attention for its possible roles in treating various medical conditions due to its unique sulfonamide and phenolic functionalities, which can enhance its biological activity.
  • Mechanism of Action: Studies suggest that compounds with similar structures may work by inhibiting certain enzymes or pathways in biological systems, making them valuable in drug development.
  • Structural Diversity: The incorporation of an isopropylamino group adds a layer of complexity, allowing for potential interactions that could lead to improved efficacy or selectivity in biological applications.

Moreover, this compound is a part of a broader class of sulfonamides, known for their significant contributions to medicinal chemistry. The presence of both hydroxyl and amine groups highlights its potential for forming hydrogen bonds, which is crucial for interactions at molecular sites within biological systems.

A compelling aspect of studying this compound is its synthesis and characterization. Scientists often engage in synthetic challenges to create such compounds, making them not only functional but also a testament to the ingenuity inherent in chemical research. As researchers continue to explore its properties and applications, we gain deeper insights into the potential therapeutic avenues that this compound may offer.


In summary, N-[2-hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide stands out as a fascinating compound with promising implications. Its unique structure and potential biological activities make it a worthwhile subject for ongoing exploration in the fields of pharmacology and medicinal chemistry.

Synonyms
SOTERENOL
13642-52-9
Soterenolum
Methanesulfonamide, N-(2-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-
9364W7589B
2'-hydroxy-5'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide monohydrochloride
Soterenol [INN]
CHEMBL30746
N-[2-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide
Soterenolum [INN-Latin]
UNII-9364W7589B
SOTERENOL [MI]
(+/-)-SOTERENOL
SCHEMBL119138
orb1738613
DTXSID40864426
2'-Hydroxy-5'-(1-hydroxy-2-isopropylaminoethyl)methansulfonilid
2'-Hydroxy-5'-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonailide
BDBM50106804
Q27271566
2'-HYDROXY-5'-(1-HYDROXY-2-(ISOPROPYLAMINO)ETHYL)METHANESULFONAMIDE
(+/-)-2'-HYDROXY-5'-(1-HYDROXY-2-(ISOPROPYLAMINO)ETHYL)METHANESULFONAMIDE
METHANESULFONANILIDE, 2'-HYDROXY-5'-(1-HYDROXY-2-(ISOPROPYLAMINO)ETHYL)-
N-(2-Hydroxy-5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide
N-[2-Hydroxy-5-(1-hydroxy-2-isopropylamino-ethyl)-phenyl]-methanesulfonamide