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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide
State
State

At room temperature, nitrofurantoin is found in a solid state in the form of a crystalline powder. It is not soluble in water, which requires it to be formulated suitably for administration as a drug.

Melting point (Celsius)
272.00
Melting point (Kelvin)
545.15
Boiling point (Celsius)
95.50
Boiling point (Kelvin)
368.65
General information
Molecular weight
238.16g/mol
Molar mass
238.1570g/mol
Density
1.6760g/cm3
Appearence

Nitrofurantoin is a yellow to amber crystalline powder. It is commonly used as an antibiotic and is known for its distinct color.

Comment on solubility

Solubility of N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide

The solubility of N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide in various solvents can be influenced by several factors, including its chemical structure and functional groups present.

Key considerations regarding its solubility include:

  • Polarity: Due to its hydroxyl group (-OH) and imine structure, this compound may exhibit moderate to high polarity, potentially enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The presence of the hydroxyl group allows for hydrogen bonding with solvent molecules, which can significantly affect solubility.
  • Solvent Compatibility: It is likely to be more soluble in organic solvents such as methanol or ethanol, while showing limited solubility in nonpolar solvents due to its polar character.

In practical terms, users can anticipate that:

  • This compound may dissolve well in aqueous environments, thereby making it suitable for various biochemical applications.
  • It might require specific conditions, such as heating or pH adjustment, to improve solubility in certain solvents.

In summary, the solubility of N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide is likely to be influenced by its ability to engage in hydrogen bonding and its overall polarity, guiding successful usage in laboratory and industrial applications.

Interesting facts

Interesting Facts about N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide

N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide is an intriguing compound that presents a variety of potential applications and significant properties.

Chemical Context

This compound is noteworthy for its structural characteristics, consisting of a hydroxyl group and a nitro-substituted furan ring, which contributes to its unique reactivity:

  • Furan Ring: The presence of the furan ring grants this compound aromatic properties, which can be beneficial in various chemical reactions.
  • Nitro Group: The nitro group (-NO2) is known for enhancing the reactivity of compounds, making it a target for medicinal chemistry due to its involvement in biologically active molecules.

Potential Applications

The distinctive features of N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide have led researchers to explore its potential applications, including:

  • Pharmaceuticals: The compound may act as a precursor or intermediate in the synthesis of drugs, particularly those targeting specific biological pathways.
  • Materials Science: Its reactive nature can be leveraged to develop new materials with tailored properties for use in various technologies.

Research Insights

Emerging research indicates that compounds similar to N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide could potentially exhibit:

  • Antioxidant Properties: Investigations into nitro-furans have suggested they may possess antioxidant capabilities, contributing to their value in health-related applications.
  • Biological Activity: Ongoing studies are uncovering the potential of such compounds in the treatment of diseases by interacting with specific biological targets.

As research continues, N-(2-hydroxyethyl)-1-(5-nitro-2-furyl)methanimine oxide stands as a fascinating example of how complex organic chemistry can lead to the discovery of valuable substances across diverse fields. This compound is a shining example of how seemingly simple changes in molecular structure can lead to significant implications in science and industry.

Synonyms
N-(2-hydroxyethyl)-1-(5-nitro-2-furanyl)methanimine oxide
SCHEMBL192138
DTXSID50864896
DS-007572
NS00124798
Q27186302
Ethanol,2-[[(5-nitro-2-furanyl)methylene]oxidoamino]-
N-(2-Hydroxyethyl)(5-nitrofuran-2-yl)methanimine N-oxide