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N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-benzenesulfonamide

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Identification
Molecular formula
C13H21NO4S
CAS number
64265-45-8
IUPAC name
N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-benzenesulfonamide
State
State
The compound is typically found as a solid at room temperature. It exists in the form of a crystalline powder which remains stable under normal atmospheric conditions.
Melting point (Celsius)
75.00
Melting point (Kelvin)
348.15
Boiling point (Celsius)
477.20
Boiling point (Kelvin)
750.40
General information
Molecular weight
273.35g/mol
Molar mass
273.3540g/mol
Density
1.1720g/cm3
Appearence

The compound is typically a colorless to pale yellow crystalline solid or powder. It may appear translucent under light, and when pure, it tends to be free of any discernible odor. The exact appearance can vary slightly depending on the specific crystalline form and the level of impurities present.

Comment on solubility

Solubility of N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-benzenesulfonamide

The solubility of N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-benzenesulfonamide (C13H21NO4S) is influenced by a number of factors including its molecular structure and the presence of functional groups. This compound, a sulfonamide derivative, exhibits distinct solubility characteristics:

  • Polar Nature: The presence of hydroxy groups (-OH) contributes to its polar nature, enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvent molecules can significantly increase solubility.
  • Solvent Interactions: It may show moderate solubility in organic solvents due to its aromatic structure, which can engage in π-π stacking or hydrophobic interactions.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with temperature, facilitating dissolution in both aqueous and organic solvents.

In summary, while N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-benzenesulfonamide demonstrates a tendency to be soluble in water and certain organic solvents, precise solubility data may vary based on environmental conditions and the specific concentration of the compound. Understanding these solubility properties is crucial for its applications in various chemical processes.

Interesting facts

Interesting Facts about N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-benzenesulfonamide

N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-benzenesulfonamide, often abbreviated as HEMPS, is a fascinating compound in the realm of medicinal chemistry. This compound is noteworthy for a number of reasons:

  • Dual Hydroxy Groups: The presence of two hydroxy groups in its structure not only enhances the solubility of HEMPS in biological systems but also contributes to its ability to form hydrogen bonds, which is vital for its interaction with biological targets.
  • Functional Versatility: HEMPS is classified as a sulfonamide. Sulfonamides are known for their diverse pharmacological activities, including antibacterial, diuretic, and carbonic anhydrase inhibitory effects, making compounds like HEMPS attractive in drug development.
  • Therapeutic Potential: The unique combination of the benzene sulfonamide group with hydroxyethyl and hydroxypropyl moieties could grant HEMPS potential applications in treating various health conditions. Research has indicated that such compounds may be effective as anti-inflammatory agents.
  • Structural Insights: The use of substituted benzene rings in medicinal compounds is common, and HEMPS exemplifies the trend of incorporating alkyl groups, like the 4-methyl, to fine-tune the biological activity and improve safety profiles.
  • Research and Development: Ongoing research into sulfonamide derivatives suggests that modifications to their structure can result in improved biological activity and reduced side effects, making HEMPS a candidate for further exploration in pharmaceutical applications.

As we explore the potential of N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-benzenesulfonamide, it not only emphasizes the importance of structural modifications in medicinal chemistry but also inspires continued innovation in the aesthetic and practical applications of organic compounds.

Synonyms
26831-90-3
n-(2-hydroxyethyl)-n-(2-hydroxypropyl)-4-methylbenzenesulfonamide
N-(2-Hydroxyethyl)-N-(2-hydroxypropyl)-p-toluenesulphonamide
EINECS 248-021-6
NSC163919
DTXSID201166994
N-(2-HYDROXYETHYL)-N-(2-HYDROXYPROPYL)-P-TOLUENESULFONAMIDE
AKOS024332400
NSC 163919
NSC-163919
NS00051212
Benzenesulfonamide, N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-4-methyl-