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N-[(2-hydroxyphenyl)methyleneamino]pyridine-4-carboxamide

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Identification
Molecular formula
C13H11N3O2
CAS number
70931-49-6
IUPAC name
N-[(2-hydroxyphenyl)methyleneamino]pyridine-4-carboxamide
State
State

At room temperature, N-[(2-hydroxyphenyl)methyleneamino]pyridine-4-carboxamide exists as a solid. Due to its molecular structure and intermolecular interactions, it maintains this solid state under standard atmospheric pressure.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.15
Boiling point (Celsius)
640.00
Boiling point (Kelvin)
913.15
General information
Molecular weight
253.26g/mol
Molar mass
253.2550g/mol
Density
1.3140g/cm3
Appearence

N-[(2-hydroxyphenyl)methyleneamino]pyridine-4-carboxamide appears as a crystalline solid. The compound typically forms needle-like crystals and varies in color, which can range from off-white to pale yellow depending on purity and form.

Comment on solubility

Solubility of N-[(2-hydroxyphenyl)methyleneamino]pyridine-4-carboxamide

The solubility of N-[(2-hydroxyphenyl)methyleneamino]pyridine-4-carboxamide in various solvents is an important consideration for its application in chemical and pharmaceutical contexts. This compound, with its complex structure, exhibits varying degrees of solubility based on several factors:

  • Solvent Polarity: It tends to dissolve better in polar solvents due to the presence of functional groups that can form hydrogen bonds.
  • Temperature: An increase in temperature often enhances solubility, allowing more molecules to enter solution.
  • pH Levels: As an amide and phenolic compound, the ionization state can affect solubility; thus, varying the pH can significantly impact its solubility behavior.
  • Concentration: At higher concentrations, solubility limits may be reached, leading to precipitation.

In summary, this compound's solubility is influenced by its chemical structure and environmental conditions. Evaluating solubility not only aids in understanding its behavior in solutions but also assists in optimizing its use in various formulations and reactions.

Interesting facts

N-[(2-Hydroxyphenyl)methyleneamino]pyridine-4-carboxamide

N-[(2-hydroxyphenyl)methyleneamino]pyridine-4-carboxamide is a fascinating compound with several noteworthy attributes that make it of interest in various scientific fields. Here are some intriguing facts regarding this compound:

  • Complex Structure: The compound features a unique hybrid structure that combines a pyridine ring with both amine and carboxamide functional groups. This complexity often allows for interesting chemical behavior and reactivity.
  • Biological Activities: Compounds like this one are frequently studied for their potential biological properties. Some derivatives may exhibit antibacterial, antifungal, or even anticancer activities, making them candidates for pharmaceutical research.
  • Enzyme Inhibition: This type of compound can sometimes act as inhibitors in biological pathways, meaning they could influence enzyme activity. Scientists are keen on understanding these interactions for drug development.
  • Coordination Chemistry: The nitrogen atoms present in the amine and carboxamide functional groups can coordinate with metal ions. This aspect opens up studies related to the design of metal complexes for various applications, including catalysis and materials science.
  • Synthesis Derivatives: The presence of multiple functional groups allows for the synthesis of numerous derivatives. Each new derivative may bring about altered properties, leading researchers to explore a range of applications.
  • Research Applications: This compound is often a subject in medicinal chemistry studies, particularly in the design of new drugs. Its ability to interact with biological molecules makes it a valuable compound for therapeutic advancements.

In summary, N-[(2-hydroxyphenyl)methyleneamino]pyridine-4-carboxamide exemplifies the intersection of organic chemistry and medicinal research, showcasing how small changes in molecular structure can yield significant differences in biological activity and chemical behavior. The study of such compounds continues to enrich our understanding of the potential for innovative therapeutic agents.

Synonyms
salicylaldehyde isonicotinoyl hydrazone
N-[(2-hydroxyphenyl)methylideneamino]pyridine-4-carboxamide
N'-[(2-HYDROXYPHENYL)METHYLIDENE]PYRIDINE-4-CARBOHYDRAZIDE
DTXSID0046272
Salinazid 100 microg/mL in Acetonitrile
CBDivE_001657
VBIZUNYMJSPHBH-UHFFFAOYSA-N
HMS2231I23
HMS3371L08
DB-051650