Skip to main content

Loperamide Hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C29H34ClN3O2
CAS number
34552-83-5
IUPAC name
N-(2-methyl-1-phenyl-2-piperidin-1-ium-1-yl-propylidene)-2-phenyl-acetamide;chloride
State
State

At room temperature, loperamide hydrochloride is typically in a solid state as a powder.

Melting point (Celsius)
225.50
Melting point (Kelvin)
498.70
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
513.52g/mol
Molar mass
513.5150g/mol
Density
1.0000g/cm3
Appearence

Loperamide hydrochloride presents as a white to off-white powder. It is usually odorless and has a bitter taste.

Comment on solubility

Solubility of N-(2-methyl-1-phenyl-2-piperidin-1-ium-1-yl-propylidene)-2-phenyl-acetamide;chloride

The solubility of N-(2-methyl-1-phenyl-2-piperidin-1-ium-1-yl-propylidene)-2-phenyl-acetamide;chloride is influenced by several factors due to its complex structure. Here are some key points regarding its solubility:

  • Polarity: The ionic chloride component tends to enhance solubility in polar solvents, such as water, while the large organic moieties may limit solubility in non-polar solvents.
  • Solvent Interaction: Its solubility may significantly depend on the solvent's ability to interact with the molecule. For example, it may be more soluble in polar aprotic solvents.
  • Temperature: Increasing temperature often enhances solubility for many compounds, and this compound might behave similarly, dissolving better at higher temperatures.
  • Concentration: At high concentrations, solubility limits may approach, leading to precipitation in solution.

As a general observation, charged species like this compound tend to have better solubility in aqueous environments compared to their neutral counterparts. Researchers have reported that compounds with similar structural features often exhibit moderate to high solubility in organic solvents while losing some solubility in purely aqueous conditions.

Understanding the solubility of this compound is essential for its applications, as it affects bioavailability and reactivity in chemical processes. Therefore, conducting solubility tests across various solvents and conditions is often recommended to ascertain its full profile.

Interesting facts

Interesting Facts about N-(2-Methyl-1-phenyl-2-piperidin-1-ium-1-yl-propylidene)-2-phenyl-acetamide;chloride

This intriguing compound belongs to a class of chemical substances that exhibit both pharmacological and therapeutic properties, making it a point of interest in medicinal chemistry. Here are some key insights:

  • Diverse Functional Groups: The structure comprises multiple functional groups including amides and quaternary ammonium ions, which contribute to its biological activity.
  • Potential Applications: Given its complex arrangement, this compound is suspected to have applications in the development of antidepressants, analgesics, and antipsychotics.
  • Mechanism of Action: Compounds like this may interact with various neurotransmitter systems, potentially influencing mood and cognitive functions by altering neurotransmitter levels.
  • Synthetic Pathways: The synthesis of this compound highlights ingenious methods in organic chemistry that combine piperidine derivatives with aromatic acetamides, showcasing the creative potential of chemists.
  • Cationic Character: As a quaternary ammonium compound, it possesses cationic characteristics that can affect its bioavailability and interaction with cellular membranes.

In the realm of scientific research, compounds like N-(2-methyl-1-phenyl-2-piperidin-1-ium-1-yl-propylidene)-2-phenyl-acetamide;chloride help us to grasp the complexity of molecular interactions and their implications on pharmacology. As such, it serves as a significant subject for ongoing studies aimed at unveiling new therapeutic pathways.

Synonyms
Acetamide, N-(alpha-(1-methyl-1-piperidinoethyl)benzylidene)-2-phenyl-, hydrochloride
13430-13-2
1-(1,1-Dimethyl-2-phenacetylimino-2-phenylethyl)piperidine hydrochloride
N-(alpha-(1-Methyl-1-piperidinoethyl)benzylidene)phenacetamide hydrochloride