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Furazolidone

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Identification
Molecular formula
C8H7N3O5
CAS number
67-45-8
IUPAC name
N-[2-methyl-5-(5-nitro-2-furyl)-1,2,4-triazol-3-yl]acetamide
State
State

At room temperature, furazolidone is typically a solid.

Melting point (Celsius)
253.00
Melting point (Kelvin)
526.15
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.15
General information
Molecular weight
225.16g/mol
Molar mass
225.1610g/mol
Density
1.4970g/cm3
Appearence

Furazolidone appears as a yellow crystalline powder. It is odorless or may have a slight characteristic smell. When exposed to light, it may darken in color.

Comment on solubility

Solubility Overview

N-[2-methyl-5-(5-nitro-2-furyl)-1,2,4-triazol-3-yl]acetamide is a compound characterized by its intricate structure and potential applications in various fields. Understanding its solubility is critical for its use in both laboratory and industrial settings.

General Solubility Characteristics

The solubility of this compound can be influenced by various factors:

  • Polarity: The presence of polar groups (like the amide functional group) suggests that this compound may exhibit moderate solubility in polar solvents such as water and ethanol.
  • Hydrophobic Regions: The structure incorporates a furan ring, which is hydrophobic in nature. This may limit solubility in highly polar solvents.
  • pH Dependence: Solubility can also vary with pH changes. Amides can be affected by acidic or basic conditions, potentially enhancing or reducing solubility.
  • Temperature Influence: Increasing temperature often enhances solubility, making it a critical consideration in practical applications.

Solubility in Practical Applications

This compound's solubility properties are crucial for:

  • Formulation in pharmaceuticals, where effective dissolution impacts bioavailability.
  • Experimental processes where accurate concentrations are necessary for controlled reactions.
  • Environmental studies investigating its behavior in various ecological solvents.

In conclusion, while exact solubility data for N-[2-methyl-5-(5-nitro-2-furyl)-1,2,4-triazol-3-yl]acetamide may require further empirical investigation, attention to its polarity, functional groups, and conditions can provide a foundational understanding of its solubility characteristics.

Interesting facts

Interesting Facts about N-[2-methyl-5-(5-nitro-2-furyl)-1,2,4-triazol-3-yl]acetamide

N-[2-methyl-5-(5-nitro-2-furyl)-1,2,4-triazol-3-yl]acetamide is a fascinating compound with unique properties and applications that capture the interest of chemists and researchers alike. Here are some noteworthy points about this intriguing compound:

  • Triazole Framework: The compound features a 1,2,4-triazole ring which is known for its biological significance. Triazoles are often utilized in medicinal chemistry as they exhibit a range of biological activities, including antifungal and antibacterial effects.
  • Nitro Group: The presence of the nitro group at the 5-position of the furan ring enhances the compound's reactivity and potential for further functionalization, making it a useful precursor in organic synthesis.
  • Agrochemical Potential: Compounds like N-[2-methyl-5-(5-nitro-2-furyl)-1,2,4-triazol-3-yl]acetamide are of significant interest in the field of agrochemicals, particularly as potential herbicides or fungicides due to their ability to interact with biological systems at a molecular level.
  • Structural Diversity: The introduction of a methyl group at the 2-position of the triazole and various modifications can lead to a wide range of derivatives that could exhibit different physical, chemical, and biological properties.
  • Pharmaceutical Relevance: Research indicates that triazole-containing compounds can enhance the effectiveness of certain medications. Their ability to act as enzyme inhibitors or modulators makes them valuable in designing new therapeutic agents.

In conclusion, N-[2-methyl-5-(5-nitro-2-furyl)-1,2,4-triazol-3-yl]acetamide illustrates how a single chemical structure can have multiple dimensions of applicability, ranging from agriculture to pharmaceuticals. Its study not only enriches our understanding of triazole chemistry but also opens avenues for innovative solutions in the science of health and sustainability.

Synonyms
10187-79-8
BRN 1145789
ACETAMIDE, N-(1-METHYL-3-(5-NITRO-2-FURYL)-s-TRIAZOL-5-YL)-
s-Triazole, 5-acetamido-1-methyl-3-(5-nitro-2-furyl)-
DTXSID30144305
Acetamide, N-(1-methyl-3-(5-nitro-2-furyl)-1H-1,2,4-triazol-5-yl)-
DTXCID5066796
N-[2-methyl-5-(5-nitrofuran-2-yl)-1,2,4-triazol-3-yl]acetamide
N-[1-Methyl-3-(5-nitro-2-furyl)-1H-1,2,4-triazol-5-yl]acetamide
N-(1-Methyl-3-(5-nitrofuran-2-yl)-1H-1,2,4-triazol-5-yl)acetamide
Acetamide, N-[1-methyl-3-(5-nitro-2-furanyl)-1H-1,2,4-triazol-5-yl]-