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N-(2-(methylamino)ethyl)isoquinoline-5-sulfonamide

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Identification
Molecular formula
C12H15N3O2S
CAS number
97461-63-9
IUPAC name
N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
State
State

At room temperature, N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide is a solid.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
475.00
Boiling point (Kelvin)
748.15
General information
Molecular weight
277.33g/mol
Molar mass
277.3500g/mol
Density
1.3000g/cm3
Appearence

N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide typically appears as an off-white to yellow crystalline powder. The crystals are often fine and can vary in shade depending on purity and specific formulations.

Comment on solubility

Solubility of N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide

The solubility of N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide (C12H15N3O2S) presents interesting characteristics due to its chemical structure. This compound is influenced by several factors that affect its solubility in various solvents.

Key Factors Influencing Solubility:

  • Polarity: The presence of sulfonamide functional groups generally increases polarity, enhancing solubility in polar solvents such as water.
  • Hydrophobic Regions: The isoquinoline moiety contributes to hydrophobic characteristics, which can limit solubility in aqueous solutions but enhance solubility in organic solvents.
  • pH Sensitivity: The protonation of the amine group may vary with pH, altering the overall charge and thereby influencing solubility in different environments.

Overall, N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide is likely to exhibit:

  • Increased solubility in polar solvents such as water due to its functional groups.
  • Limited solubility in non-polar solvents due to hydrophobic interactions.
  • Variable solubility at different pH levels, reflecting changes in ionic states.

As a result, the understanding of this compound's solubility is crucial, especially when considering its applications in pharmaceuticals and chemical research.

Interesting facts

Interesting Facts about N-[2-(Methylamino)ethyl]isoquinoline-5-sulfonamide

N-[2-(Methylamino)ethyl]isoquinoline-5-sulfonamide is an intriguing chemical compound that draws interest from both medicinal chemistry and organic synthesis fields. Here are some fascinating aspects of this compound:

  • Structural Complexity: This compound features a unique structure that includes an isoquinoline moiety. This heterocyclic aromatic compound is often found in various natural products and pharmaceuticals, making it a subject of interest in drug development.
  • Potential Biological Activity: Isoquinoline derivatives are known for their diverse range of biological activities, including antibacterial, antifungal, and antiviral properties. Researchers are investigating compounds like this one for their potential therapeutic roles.
  • Importance of Sulfonamide Group: The sulfonamide (-SO2NH2) functionality is prominent in many drugs, particularly antibiotics. It acts as a pharmacophore and is involved in crucial interactions with biological targets, contributing to the compound's biological efficacy.
  • Synthetic Applications: The compound showcases the versatility of synthetic methods in organic chemistry. Its synthesis involves various techniques including amination and sulfonation, making it relevant for educational purposes and research in synthetic organic chemistry.
  • Exploration in Drug Design: As pharmaceutical researchers continue to explore novel drug candidates, derivatives like N-[2-(Methylamino)ethyl]isoquinoline-5-sulfonamide offer a valuable platform for developing new medications targeting various diseases.

This compound exemplifies the intersection of synthetic intrigue and biological potential. Its structure and functionality make it a worthwhile subject for further investigation and experimentation in the field of medicinal chemistry.

Synonyms
84478-11-5
N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide
N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
h-8
Protein kinase inhibitor H-8
H-8 Protein kinase inhibitor
H8 protein kinase inhibitor
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
Protein kinase inhibitor H8
(5-Isoquinolylsulfonyl)[2-(methylamino)ethyl]amine
CHEBI:43561
Lopac-M-9656
Protein kinase inhibitor 7
N-(2-(Methylamino)ethyl)isoquinoline-5-sulfonamide
5-Isoquinolinesulfonamide,N-[2-(methylamino)ethyl]-
5-Isoquinolinesulfonamide, N-(2-(methylamino)ethyl)-
CHEMBL148333
TX277E49WT
DTXSID20233454
(5-Isoquinolylsulfonyl)(2-(methylamino)ethyl)amine
N-(2-methylaminoethyl)isoquinoline-5-sulfonamide
5-isoquinolinesulfonamide, N-[2-(methylamino)ethyl]-
1yds
N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE-
BiomolKI_000036
H 8 (enzyme inhibitor)
BiomolKI2_000044
UNII-TX277E49WT
Lopac0_000822
GTPL2348
SCHEMBL1272378
BDBM15210
BRD2343
DTXCID20155945
PJWUXKNZVMEPPH-UHFFFAOYSA-N
BRD-2343
HSCI1_000300
AKOS009158953
N-(2-(Methylamino)ethyl)isoquinoline- 5-sulfonamide dihydrochloride (H8)
CCG-100640
DB07997
SDCCGSBI-0050799.P003
SDCCGSBI-0050799.P007
NCGC00015709-01
NCGC00015709-02
NCGC00015709-03
NCGC00015709-04
NCGC00162263-01
NCGC00162263-02
HY-155619
CS-0882846
NS00038518
N-(2-methylaminoethyl)-5-isoquinolinesulfonamide
EN300-14783236
BRD-K18742343-001-03-2
Q27077964
617-573-3
H 8