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Venlafaxine

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Identification
Molecular formula
C17H27NO2
CAS number
93413-69-5
IUPAC name
N-(2-morpholinoethyl)-2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propan-1-amine
State
State

At room temperature, Venlafaxine is typically in a solid crystalline state, often processed into a tablet or encapsulated form for pharmacological use.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
530.60
Boiling point (Kelvin)
803.80
General information
Molecular weight
277.40g/mol
Molar mass
277.4010g/mol
Density
1.1208g/cm3
Appearence

Venlafaxine is usually found as a white to off-white crystalline solid. It is typically odorless and tasteless in its pure form. It is often encountered as a powder for oral consumption or as a tablet depending on its pharmaceutical preparation.

Comment on solubility

Solubility of N-(2-morpholinoethyl)-2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propan-1-amine (C17H27NO2)

The solubility of N-(2-morpholinoethyl)-2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propan-1-amine, often referred to simply as a morpholino compound, can be influenced by several factors. While specific solubility data might not always be readily available, some general observations can be made:

  • Polarity: The presence of the morpholino group typically enhances solubility in polar solvents, such as water and ethanol, due to its ability to form hydrogen bonds.
  • Hydrophobic Interactions: The naphthylmethyl moiety suggests that there can be significant hydrophobic interactions, potentially limiting solubility in purely aqueous environments.
  • pH Dependency: The solubility might also vary with pH, as the amino groups could be protonated in acidic conditions, affecting overall solubility.
  • Temperature Influence: As with many organic compounds, increasing the temperature can enhance solubility, facilitating dissolution.

In conclusion, while N-(2-morpholinoethyl)-2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propan-1-amine may exhibit moderate solubility in polar solvents, factors such as its specific chemical structure, environmental pH, and temperature must be considered to fully understand its solubility profile. Understanding these properties is crucial for applications in pharmaceutical formulation and development.

Interesting facts

Interesting Facts about N-(2-morpholinoethyl)-2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propan-1-amine

N-(2-morpholinoethyl)-2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propan-1-amine is a fascinating compound that showcases the intricate relationship between structure and function in organic chemistry. This compound, featuring a combination of a morpholine ring and a naphthyl group, presents remarkable potential in various applications, especially in the field of medicinal chemistry.

Chemical Structure and Significance

  • Morpholine Component: The presence of the morpholino group provides the compound with unique pharmacological properties, enhancing solubility and bioavailability.
  • 1-Naphthylmethyl Group: This aromatic moiety contributes significantly to the compound's physicochemical properties, influencing its ability to interact with biological targets.
  • Tetrahydrofuran Ring: The tetrahydrofuran moiety adds cyclic structure, offering steric hindrance which can be crucial in drug design.

Applications in Medicinal Chemistry

This compound's unique structure leads to numerous potential applications:

  • Analgesic Properties: Due to its structural motifs, it may exhibit interactions with pain pathways in the nervous system, making it a candidate for pain relief.
  • Aid for Neurological Disorders: The ability to traverse the blood-brain barrier suggests potential use in treatments for conditions such as depression or anxiety.

Quote to Remember

"In the world of chemistry, the smallest changes in structure can lead to monumental differences in function." – Anonymous

Conclusion

The intricate design of N-(2-morpholinoethyl)-2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propan-1-amine exemplifies how organic chemistry interlinks molecular structure and biological activity. Continued research into this compound may reveal further therapeutic opportunities.