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N-(2-Phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazinyl]propanamide

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Identification
Molecular formula
C17H19N3O2
CAS number
52809-07-1
IUPAC name
N-(2-phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazino]propanamide
State
State

This compound is solid at room temperature, with a crystalline appearance.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.20
Boiling point (Celsius)
525.50
Boiling point (Kelvin)
798.70
General information
Molecular weight
307.36g/mol
Molar mass
307.3600g/mol
Density
1.2800g/cm3
Appearence

N-(2-Phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazinyl]propanamide is typically a white to off-white crystalline solid. Its physical appearance can vary slightly depending on purity and specific conditions of synthesis or storage, but in general, it presents in crystalline form.

Comment on solubility

Solubility of N-(2-phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazino]propanamide

Understanding the solubility of the compound N-(2-phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazino]propanamide is critical in various applications, including pharmaceuticals and research. This compound presents unique solubility characteristics due to its complex structure.

Factors Influencing Solubility

Several factors can affect the solubility of this compound:

  • Polarity: Given the presence of both hydrophobic (phenyl group) and polar (carbonyl and amine groups) components, the overall polarity of the molecule plays a crucial role in its solubility.
  • Solvent Type: Solubility is often solvent-dependent. N-(2-phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazino]propanamide may dissolve better in polar organic solvents such as DMSO or DMF rather than in non-polar solvents.
  • pH Levels: The solubility might vary with changes in pH, especially due to possible ionization of the amine or carbonyl functionalities.

General Observations

It is generally observed that:

  • Hydrophobic interactions might lead to lower solubility in aqueous solutions.
  • Hydrogen bonding interactions enhance solubility in polar solvents.
  • Compounds similar in structure often show limited aqueous solubility, indicating that the addition of hydrophilic groups could improve this property.

In summary, the solubility of N-(2-phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazino]propanamide is influenced by its molecular structure, the nature of the surrounding solvent, and the conditions under which solubility is tested. Understanding these aspects can facilitate better formulation and application of this compound.

Interesting facts

Interesting Facts about N-(2-phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazino]propanamide

N-(2-phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazino]propanamide is a fascinating compound with notable significance in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Structural Composition: This chemical boasts a complex structure that features both a hydrazine functional group and an amide linkage. The incorporation of a pyridine ring adds to its versatility and may enhance its biological activity.
  • Biological Implications: Compounds containing hydrazine derivatives have often been investigated for their potential therapeutic effects. Studies suggest that such compounds might exhibit activities related to anti-tumor, anti-inflammatory, and even antimicrobial properties.
  • Research Focus: The combination of hydrazine with a pyridine backbone has attracted attention in the field of drug design. Researchers are exploring how this particular arrangement can influence pharmacological profiles, leading to the development of novel medications.
  • Hydrazine Chemistry: Interestingly, hydrazines are known to participate in various chemical reactions, making them valuable intermediates in organic synthesis. The hydrazone formation is one of the key reactions, often utilized for creating more complex molecules.
  • Solubility and Activity: The unique combination of the phenyl and pyridine rings can contribute to the compound's solubility profile, which is crucial for bioavailability in pharmacological applications. Understanding how these factors affect drug activity is a central theme in drug development.

In summary, N-(2-phenylethyl)-3-[2-(pyridine-4-carbonyl)hydrazino]propanamide represents an interesting intersection of organic synthesis and medicinal chemistry, positioning it as a compound worthy of further exploration and study.

Synonyms
P 1234
BRN 0494394
ISONICOTINIC ACID, 2-(2-(PHENETHYLCARBAMOYL)ETHYL)HYDRAZIDE
15563-29-8
DTXSID20165943
DTXCID8088434