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N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide

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Identification
Molecular formula
C13H18ClNO
CAS number
103003-13-6
IUPAC name
N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide
State
State

At room temperature, N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide is a solid. This state is typical for many organic compounds with relatively complex structures at standard laboratory conditions.

Melting point (Celsius)
94.50
Melting point (Kelvin)
367.70
Boiling point (Celsius)
361.40
Boiling point (Kelvin)
634.50
General information
Molecular weight
239.74g/mol
Molar mass
239.7420g/mol
Density
1.1200g/cm3
Appearence

The compound N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide is typically a white to off-white crystalline solid. The appearance may vary slightly due to impurities or different forms (e.g., polymorphs).

Comment on solubility

Solubility of N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide

N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide is an intriguing compound, particularly when it comes to its solubility characteristics. The solubility of this compound can be influenced by several factors:

  • Polarity: Due to the presence of both hydrophobic (the tert-butyl group) and hydrophilic (the acetamide functional group) elements, the solubility can vary in different solvents.
  • Solvent Type: This compound is generally more soluble in polar organic solvents such as ethanol or acetonitrile, while having limited solubility in non-polar solvents.
  • Temperature: Increasing the temperature often enhances solubility; therefore, careful temperature control may be necessary to achieve optimal results in solvation.

To quote a common principle in chemistry, "like dissolves like," which emphasizes the importance of matching the polarity of solvents with that of the solute. For N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide, understanding its solubility behavior can be essential for applications in drug design and synthesis. Experimentation and solubility testing in various solvents will yield the best insights into its practical use.

Interesting facts

Interesting Facts about N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide

N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide, a compound with intriguing properties and potential applications, has attracted attention in various fields, particularly in medicinal chemistry and materials science. Here are some fascinating aspects of this compound:

  • Structural Features: The presence of the tert-butyl group and the chloromethyl moiety enhances the molecule's lipophilicity, making it a candidate for further modification to improve pharmacological efficacy.
  • Biological Activity: Compounds similar to N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide have been investigated for their potential anti-inflammatory and analgesic properties, showcasing the importance of such derivatives in drug discovery.
  • Reactivity: The chloromethyl group in the structure may act as a reactive site, allowing for diverse synthetic transformations that can yield a variety of functional derivatives useful in research and application.
  • Applications in Material Science: Compounds featuring bulky substituents like tert-butyl can contribute to the design of high-performance polymers, enhancing thermal and mechanical properties.
  • Intermolecular Interactions: The unique structure may participate in interesting intermolecular interactions, making it a model system for studies in supramolecular chemistry.

This compound exemplifies how slight modifications in chemical structures can lead to significant changes in properties and reactivities, opening doors to innovative applications in chemistry and beyond. As noted by researchers, "The future of synthetic compounds lies in understanding the intricate relationships between structure and function."

In summary, N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide serves as a promising framework for exploring the rich tapestry of organic chemistry and its applications.

Synonyms
Monsanto 31675
3785-20-4
2-Chloro-N-(2-methyl-6-tert-butylphenyl)acetamide
CP 31675
2-tert-Butyl-6-methylchloroacetanilide
BRN 2730032
o-Acetotoluidide, 6'-tert-butyl-2-chloro-
Acetamide, 2-chloro-N-(2-(1,1-dimethylethyl)-6-methylphenyl)-
Acetamide, 2-chloro-N-(2-(1,1-dimethylethyl)-6-methylphenyl)-(9CI)
N-[2-tert-butyl-6-(chloromethyl)phenyl]acetamide
SCHEMBL7217437
DTXSID80958878
N-[2-tert-Butyl-6-(chloromethyl)phenyl]ethanimidic acid