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N-(2-Thienylmethyl)acetamide

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Identification
Molecular formula
C7H9NOS
CAS number
2114-19-2
IUPAC name
N-(2-thienylmethyl)acetamide
State
State
N-(2-Thienylmethyl)acetamide is typically found in a solid state at room temperature. It is stable under standard conditions and does not readily volatilize.
Melting point (Celsius)
92.00
Melting point (Kelvin)
365.15
Boiling point (Celsius)
292.70
Boiling point (Kelvin)
565.85
General information
Molecular weight
169.23g/mol
Molar mass
169.2320g/mol
Density
1.1854g/cm3
Appearence

N-(2-Thienylmethyl)acetamide appears as an off-white to yellowish crystalline solid. It may present in a more powdered form but generally maintains a solid, granular consistency.

Comment on solubility

Solubility of N-(2-thienylmethyl)acetamide

N-(2-thienylmethyl)acetamide is a compound that exhibits interesting solubility characteristics. The solubility of this molecule can be attributed to its structural features, particularly the presence of the thienyl group and the amide functional group, which can participate in various interactions with solvents.

Factors influencing the solubility of N-(2-thienylmethyl)acetamide include:

  • Polarity: The amide group enhances the polarity of the compound, making it more soluble in polar solvents such as water.
  • Hydrogen bonding: The ability of the amide to form hydrogen bonds increases its solubility in protic solvents.
  • Solvent interaction: The thiophene ring allows for π-π stacking interactions, which can further enhance solubility in organic solvents.

It is commonly observed that:

  1. N-(2-thienylmethyl)acetamide shows good solubility in polar aprotic solvents like DMSO and DMF.
  2. In contrast, it may exhibit limited solubility in nonpolar solvents due to the presence of the polar amide functional group.

In conclusion, the solubility profile of N-(2-thienylmethyl)acetamide demonstrates the significant influence of its molecular structure, highlighting the role of polar and nonpolar components in solvent interactions. This characteristic is essential for its applications in various chemical processes.

Interesting facts

Interesting Facts about N-(2-thienylmethyl)acetamide

N-(2-thienylmethyl)acetamide is a fascinating compound that showcases the intricate relationship between chemistry and biological activity. Here are some compelling aspects of this compound:

  • Origin of Name: The name of this compound is derived from its functional groups. The "N-" indicates an amide linkage, while "2-thienylmethyl" refers to the presence of a thiophene ring, which is a five-membered aromatic heterocycle containing sulfur.
  • Biological Relevance: Compounds like N-(2-thienylmethyl)acetamide have been studied for their potential pharmacological properties, particularly in the realm of medicinal chemistry. They may exhibit activities such as anti-inflammatory and analgesic effects.
  • Synthesis Routes: The synthesis of this compound involves the combination of thiophene derivatives with acetamide groups, often necessitating the use of specific catalysts and reaction conditions to ensure high yields and purity.
  • Research Applications: The study of this compound can lead to insights on how modifications to the thiophene structure can alter biological activity, paving the way for the design of new pharmaceuticals.
  • Future Prospects: Ongoing research is likely to focus on the development of more effective derivatives that could lead to advancements in drug discovery targeting various diseases.

In conclusion, N-(2-thienylmethyl)acetamide represents a unique intersection of organic chemistry and medicinal research, where the exploration of its properties can have meaningful implications in health and disease management.

Synonyms
N-[(Thiophen-2-yl)methyl]acetamide
N-((thiophen-2-yl)methyl)acetamide
RefChem:823258
866-754-5
21403-24-7
N-(thiophen-2-ylmethyl)acetamide
N-(thien-2-ylmethyl)acetamide
N-(2-thienylmethyl)acetamide
2-Thenylacetamide
BRN 0116637
ACETAMIDE, N-2-THENYL-
N-acetyl-2-thenylamine
2-acetylaminomethylthiophene
SCHEMBL885325
SCHEMBL3140988
SCHEMBL3605990
SCHEMBL11585105
DTXSID00943963
BQRIKSCISYLMQV-UHFFFAOYSA-N
HMS1776M16
WAA40324
AKOS001136644
NCGC00329364-01
N-[(Thiophen-2-yl)methyl]ethanimidic acid
CS-0245626
ST51026902
EN300-30758
G34013
AB01322974-02
4-18-00-07104 (Beilstein Handbook Reference)
Z29693692