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Interesting Facts about N-(2,2-dichloro-1-hydroxy-ethyl)-2-(4-fluorophenyl)acetamide

N-(2,2-dichloro-1-hydroxy-ethyl)-2-(4-fluorophenyl)acetamide, also known by its common name in pharmacology, exhibits fascinating properties that make it a subject of interest in medicinal chemistry. Here are some key points to consider:

• Pharmacological Relevance: This compound has been studied for its potential applications in treating various conditions due to its unique structure and reactivity, especially its chlorinated and fluorinated functional groups.
• Structure-Activity Relationship (SAR): The incorporation of both fluorine and chlorine atoms significantly alters the electronic distribution and hydrophobicity of the molecule, making it a valuable compound for SAR studies in drug design.
• Stability and Reactivity: The presence of the chloro and hydroxy groups enhances the stability of the acetamide moiety, allowing for a more robust interaction with biological targets.
• Synthetic Applications: Its synthesis often involves multi-step processes that can highlight various organic reactions such as nucleophilic substitution and acylation, providing an excellent educational opportunity for students learning organic chemistry techniques.

Moreover, one of the exciting aspects of this compound is how it reflects trends in modern medicinal chemistry where halogen substituents are frequently utilized to enhance the bioavailability and efficacy of pharmaceutical agents. As stated by chemical researchers, "the selective introduction of halogens can lead to compounds that more effectively interact with enzyme targets."

All in all, N-(2,2-dichloro-1-hydroxy-ethyl)-2-(4-fluorophenyl)acetamide stands out as a compelling compound that not only contributes to our understanding of structure-function relationships in drug design but also serves as a valuable example in organic synthesis education.