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N-(2,2,2-trifluoroethyl)aniline

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Identification
Molecular formula
C8H8F3N
CAS number
400-47-3
IUPAC name
N-(2,2,2-trifluoroethyl)aniline
State
State

At room temperature, N-(2,2,2-trifluoroethyl)aniline is a liquid. Its presence is usually in the form of a clear to pale yellow solution.

Melting point (Celsius)
-8.10
Melting point (Kelvin)
265.05
Boiling point (Celsius)
183.00
Boiling point (Kelvin)
456.15
General information
Molecular weight
173.15g/mol
Molar mass
173.1540g/mol
Density
1.2560g/cm3
Appearence

N-(2,2,2-Trifluoroethyl)aniline typically appears as a colorless to light yellow liquid. Its clarity can vary, and it should be handled carefully under laboratory conditions.

Comment on solubility

Solubility of N-(2,2,2-trifluoroethyl)aniline

N-(2,2,2-trifluoroethyl)aniline showcases unique solubility characteristics due to its molecular structure. Understanding its solubility can provide valuable insights into its behavior in different environments. Here are some key points regarding its solubility:

  • Polar Nature: The presence of the trifluoroethyl group contributes to the polar nature of N-(2,2,2-trifluoroethyl)aniline, impacting its interaction with solvents.
  • Solvent Compatibility: This compound is generally soluble in polar solvents, such as:
    • Water
    • Methanol
    • Acetonitrile
  • Limited Solubility: However, it may have limited solubility in non-polar solvents, which is typical for compounds with significant polar functional groups.
  • Hydrogen Bonding: The amino group (-NH2) in the aniline structure allows for potential hydrogen bonding, enhancing solubility in polar environments.

In conclusion, N-(2,2,2-trifluoroethyl)aniline is primarily soluble in polar solvents due to its polar functional groups, but caution should be considered when predicting its behavior in non-polar settings. Understanding the nuances of its solubility can facilitate its application in various chemical processes.

Interesting facts

Interesting Facts about N-(2,2,2-trifluoroethyl)aniline

N-(2,2,2-trifluoroethyl)aniline is a fascinating compound that has garnered attention due to its unique properties and applications. Here are some intriguing aspects of this compound:

  • Fluorinated Features: The presence of trifluoroethyl groups imparts remarkable characteristics, including increased lipophilicity which can enhance the compound’s ability to cross biological membranes.
  • Applications in Research: This compound is often utilized in medicinal chemistry as a building block for creating various pharmaceutical agents, allowing for the development of novel drugs.
  • Structure-Activity Relationship (SAR): Researchers often study the SAR of compounds like N-(2,2,2-trifluoroethyl)aniline to understand how the trifluoroethyl group influences biological activity, making it a handy tool in drug design.
  • Environmental Considerations: Due to the strong C-F bonds, compounds containing fluorinated groups tend to be resistant to degradation, prompting discussions on their environmental impact and stability.
  • The Aniline Backbone: Aniline derivatives, such as this one, are key in the synthesis of dyes, agrochemicals, and other industrial chemicals, acting as versatile intermediates in organic synthesis.

In summary, N-(2,2,2-trifluoroethyl)aniline is more than just a chemical compound—it is a gateway to exploring innovative applications in various scientific fields. As we continue to understand its properties and interactions, this compound stands as a testament to the intricate relationship between structure and function in chemistry.

Synonyms
N-(2,2,2-Trifluoroethyl)aniline
351-61-1
BRN 2716921
ANILINE, N-(2,2,2-TRIFLUOROETHYL)-
DTXSID80188597
4-12-00-00251 (Beilstein Handbook Reference)
MFCD01670295
Benzenamine, N-(2,2,2-trifluoroethyl)-
SCHEMBL549076
DTXCID40111088
AKOS000253301
FS-5858
DB-230882
CS-0258959
EN300-71898
F97017
Z335250264
818-456-1