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N-[(2,3-difluorophenyl)methyl]-4-sulfamoyl-benzamide

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Identification
Molecular formula
C14H12F2N2O3S
CAS number
149-78-8
IUPAC name
N-[(2,3-difluorophenyl)methyl]-4-sulfamoyl-benzamide
State
State

At room temperature, this compound is typically a solid. It is stable under normal conditions of use and storage.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
322.00
Boiling point (Kelvin)
595.15
General information
Molecular weight
330.32g/mol
Molar mass
330.3200g/mol
Density
1.5200g/cm3
Appearence

The compound is typically found as an off-white to pale yellow crystalline powder.

Comment on solubility

Solubility of N-[(2,3-difluorophenyl)methyl]-4-sulfamoyl-benzamide

The solubility of N-[(2,3-difluorophenyl)methyl]-4-sulfamoyl-benzamide (C14H12F2N2O3S) can be influenced by several factors, making it an intriguing subject of study. Here are some key points regarding its solubility:

  • Polarity: The presence of electronegative fluorine atoms and sulfonamide functional groups increases the polarity of the compound, suggesting that it may exhibit variable solubility in polar solvents.
  • Solvent Interaction: It is likely to be more soluble in solvents such as water or DMSO compared to non-polar solvents due to the contribution of hydrogen bonding and dipole-dipole interactions.
  • Temperature Effect: As with many organic compounds, an increase in temperature can enhance solubility, allowing for greater interaction of the solute with the solvent molecules.
  • pH Sensitivity: In acidic or basic environments, the ionization of the sulfonamide group may further affect solubility, highlighting the importance of pH in solubility profiles.

In summary, while specific solubility data for N-[(2,3-difluorophenyl)methyl]-4-sulfamoyl-benzamide may be limited, understanding its chemical characteristics can provide insights into its potential behavior in various solvents. Adequate experimentation is essential to determine precise solubility values, which can significantly impact its application in medicinal chemistry and formulations.

Interesting facts

Interesting Facts About N-[(2,3-Difluorophenyl)methyl]-4-sulfamoyl-benzamide

N-[(2,3-Difluorophenyl)methyl]-4-sulfamoyl-benzamide is a fascinating compound that belongs to the class of sulfamoyl-benzamides. Here are some remarkable facts that highlight its significance and potential applications:

  • Pharmaceutical Potential: This compound is of particular interest in the pharmaceutical industry due to its potential as an inhibitor for various enzymes, contributing to therapeutic effects in treating certain diseases.
  • Fluorine Atoms: The presence of two fluorine atoms in its structure may enhance its biological activity. Fluorine is known for improving metabolic stability and increasing lipophilicity, factors that can enhance the drug-like properties of a compound.
  • Research Applications: Researchers are exploring the efficacy of compounds similar to this one in targeting specific cellular pathways. Compounds like this may hold promise in cancer therapies, especially due to their ability to disrupt tumor cell proliferation.
  • Structure-Activity Relationship (SAR): The unique molecular structure of N-[(2,3-difluorophenyl)methyl]-4-sulfamoyl-benzamide allows for interesting studies on SAR, where slight modifications to its structure can lead to significant differences in biological activity.
  • Environmental Impact: The sustainability profile of this compound is being studied, especially to understand its environmental persistence and degradation—an essential aspect for future applications and safety assessments.

As a chemist or a student, exploring such compounds not only enriches your understanding of chemical interactions but also opens avenues for creative and innovative applications in diverse fields such as medicinal chemistry, pharmacology, and environmental sciences. The intricate balance of functionality and structure in N-[(2,3-difluorophenyl)methyl]-4-sulfamoyl-benzamide serves as a reminder of the endless possibilities within the realm of chemical research.

Synonyms
N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE
235088-49-0
N-[(2,3-difluorophenyl)methyl]-4-sulfamoylbenzamide
T4Y7SN7BXW
1g52
F2B
4-(Aminosulfonyl)-N-((2,3-difluorophenyl)methyl)benzamide
N-((2,3-Bis(fluoranyl)phenyl)methyl)-4-sulfamoyl-benzamide
Benzamide, 4-(aminosulfonyl)-N-((2,3-difluorophenyl)methyl)-
N-((2,3-difluorophenyl)methyl)-4-sulfamoylbenzamide
Benzamide, 4-(aminosulfonyl)-N-[(2,3-difluorophenyl)methyl]-
2,3-difluoro-SBB
UNII-T4Y7SN7BXW
N-(2,3-Difluorobenzyl)-4-sulfamoylbenzamide
BDBM12016
DTXSID80274323
1g46
DB07742
PD005504
NS00069142
Q27096960
Z2784291117
4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE