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2,4,6-Trimethylanilide

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Identification
Molecular formula
C11H15NO
CAS number
2985-12-0
IUPAC name
N-(2,4,6-trimethylphenyl)acetamide
State
State

At room temperature, N-(2,4,6-trimethylphenyl)acetamide is typically a solid. It can be handled as a powder or in crystalline form. Care must be taken to avoid inhalation, as with many fine powders.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
177.25g/mol
Molar mass
177.2450g/mol
Density
1.0123g/cm3
Appearence

The compound appears as a white to slightly off-white crystalline solid. It may have a faint odor that is characteristic of aromatic amides. The crystals are typically small, uniform, and can sometimes exhibit a shiny or glossy surface.

Comment on solubility

Solubility of N-(2,4,6-trimethylphenyl)acetamide

N-(2,4,6-trimethylphenyl)acetamide is a compound that exhibits intriguing solubility characteristics. The solubility of this compound primarily depends on the nature of its functional groups and the overall molecular structure. Here are some points to consider:

  • Polar vs. Non-Polar: The amide functional group present in the compound enhances its solubility in polar solvents, particularly water.
  • Solvent Compatibility: It shows reasonable solubility in common organic solvents such as ethanol and acetone due to its hydrophobic aromatic rings and polar amide group.
  • Temperature Effects: Like many organic compounds, the solubility of N-(2,4,6-trimethylphenyl)acetamide may increase with temperature, potentially allowing for higher concentrations in solution.
  • Crystal Structure: The crystallinity of the compound can affect its solubility; more crystalline forms tend to have lower solubility rates compared to amorphous varieties.

Overall, while N-(2,4,6-trimethylphenyl)acetamide is not highly soluble in water, it demonstrates a moderate level of solubility in a variety of organic solvents, which makes it versatile for various applications. It’s important to always consider the specific solvent system when evaluating the solubility of this compound.

Interesting facts

Interesting Facts about N-(2,4,6-trimethylphenyl)acetamide

N-(2,4,6-trimethylphenyl)acetamide, commonly known in organic chemistry circles, showcases a unique blend of functional groups, creating opportunities for diverse applications in synthesis and medicinal chemistry. Here are some key points that highlight the significance of this compound:

  • Diverse Applications: This compound is an important building block in the synthesis of various organic molecules, such as pharmaceuticals and agrochemicals.
  • Structure-Activity Relationship: As a derivative of acetamide, it offers insights into the structure-activity relationship (SAR) of compounds, which is crucial for drug development.
  • Interesting Substituents: The presence of three methyl groups on the phenyl ring contributes to unique electronic properties and steric effects, affecting both reactivity and stability.
  • Role in Research: It is often studied in academic settings to understand reaction mechanisms and the behavior of amides in various chemical reactions.

Furthermore, the synthesis of N-(2,4,6-trimethylphenyl)acetamide can involve various methods, each providing a different perspective on its chemistry. As quoted by many chemists, "The beauty of organic chemistry lies in the intricacies of how simple building blocks interact to form complex molecules." This compound exemplifies such beauty in its elegant structure and potential.

In summary, N-(2,4,6-trimethylphenyl)acetamide serves not just as a functional compound, but as a central piece in the magical puzzle of organic synthesis and medicinal chemistry, making it an exciting area for ongoing research.

Synonyms
N-mesitylacetamide
N-(2,4,6-Trimethylphenyl)acetamide
5096-21-9
Acetamide, N-(2,4,6-trimethylphenyl)-
ACETANILIDE, 2',4',6'-TRIMETHYL-
NSC 11349
AI3-52510
DTXSID20198973
N-[2,4,6-trimethylphenyl]acetamide
DTXCID80121464
Acetamide, N-(2,4,6-trimethylphenyl)-(9CI)
664-792-5
Acetomesidide
2,4,6-Trimethylacetanilide
Y38GVE8DGZ
NSC-11349
NSC11349
2,6-Trimethylacetanilide
UNII-Y38GVE8DGZ
Acetamide, N-(2,4,6-trimethylphenyl)- (9CI)
2',6'-Trimethylacetanilide
Acetanilide,4',6'-trimethyl-
SCHEMBL2902943
Acetamide,4,6-trimethylphenyl)-
LQWWZVZGPVVZOB-UHFFFAOYSA-N
WLN: 1VMR B1 D1 F1
AKOS002951787
N-(2,4,6-trimethyl-phenyl)-acetamide
CS-0331933
VU0447137-1
AG-205/03206010