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Diclofenamide

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Identification
Molecular formula
C8H6Cl2FNO
CAS number
120-97-8
IUPAC name
N-(2,5-dichlorophenyl)-2-fluoro-acetamide
State
State

At room temperature, Diclofenamide is in a solid state.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
327.00
Boiling point (Kelvin)
600.15
General information
Molecular weight
221.05g/mol
Molar mass
221.0450g/mol
Density
1.5400g/cm3
Appearence

Diclofenamide typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-(2,5-dichlorophenyl)-2-fluoro-acetamide

N-(2,5-dichlorophenyl)-2-fluoro-acetamide exhibits solubility characteristics that are influenced by its chemical structure. Here are some key points regarding its solubility:

  • Polarity: The presence of both dichlorophenyl and fluoro groups contributes to the compound's polarity, which can affect its interaction with solvents.
  • Solvent Compatibility: This compound is generally expected to be soluble in polar organic solvents. Common examples include:
    • Dimethyl sulfoxide (DMSO)
    • Acetonitrile
    • Ethanol
  • Water Solubility: The solubility in water is likely limited due to the hydrophobic nature of the aromatic ring.
  • Temperature Influence: As with many organic compounds, increasing the temperature may enhance solubility in certain solvents.

In summary, while N-(2,5-dichlorophenyl)-2-fluoro-acetamide is expected to dissolve in several polar organic solvents, its solubility in water remains marginal. Understanding these properties is essential for effective application and utilization of the compound.

Interesting facts

Interesting Facts about N-(2,5-Dichlorophenyl)-2-fluoro-acetamide

N-(2,5-dichlorophenyl)-2-fluoro-acetamide is a fascinating compound, particularly due to its structure and potential applications. Here are some noteworthy aspects of this chemical:

  • Pharmaceutical Relevance: This compound, like many amides, has garnered interest in the field of medicinal chemistry. Its structure suggests possible anti-inflammatory and analgesic properties, making it a candidate for drug development.
  • Substituent Significance: The presence of the 2,5-dichlorophenyl group is significant. Chlorine substituents can greatly alter the biological activity of compounds. In this case, they may enhance lipophilicity or influence receptor binding.
  • Fluorine Influence: The 2-fluoro substituent is known for its unique electronic properties. Fluorine can stabilize certain pharmacological profiles and improve the overall efficacy of compounds, potentially increasing their activity against specific targets.
  • Synthetic Pathways: The synthesis of this compound involves interesting organic reactions, often including nucleophilic substitutions and specific coupling methods. Understanding these synthetic routes is crucial for advancing similar compounds in research.
  • Potential Uses: With ongoing research, compounds like N-(2,5-dichlorophenyl)-2-fluoro-acetamide could lead to discovering new therapeutic agents, particularly in treating various diseases related to inflammation and pain.

In conclusion, N-(2,5-dichlorophenyl)-2-fluoro-acetamide exemplifies how subtle changes in molecular structure can lead to significantly different properties and functionalities. As research continues to unveil the intricacies of such compounds, their potential in various fields, especially pharmacology, remains an exciting frontier.

Synonyms
2',5'-Dichloro-2-fluoroacetanilide
ACETANILIDE, 2',5'-DICHLORO-2-FLUORO-
BRN 2108447
3435-67-4
DTXSID20187923
DTXCID80110414