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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
N-(2,6-dimethylphenyl)acetamide
State
State

At room temperature, lidocaine exists as a solid substance. When formulated in commercial products, it is commonly found in liquid form in solutions or as gels and creams for topical use.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
235.34g/mol
Molar mass
235.3430g/mol
Density
0.9548g/cm3
Appearence

Lidocaine is characterized as a white, odorless, crystalline powder. It is generally encountered in its pure form as a solid and is soluble in water, alcohol, and chloroform.

Comment on solubility

Solubility of N-(2,6-dimethylphenyl)acetamide

N-(2,6-dimethylphenyl)acetamide, characterized by its organic structure, demonstrates specific solubility characteristics that are crucial for its applications in various fields. This compound is generally soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetone. However, its solubility in water is limited due to the hydrophobic nature of the aromatic function.

Key factors influencing its solubility include:

  • Polarity: The presence of the acetamide group increases polarity slightly, which helps in solubility in less polar solvents.
  • Molecular Structure: The bulky 2,6-dimethyl groups add steric hindrance, which can impact the ability to interact with solvent molecules.
  • Temperature: Like many organic compounds, solubility may increase with temperature, allowing for greater dispersion in organic solvents.

To illustrate, one might say: “The greater the molecular interaction possibilities with the solvent, the better the solubility.” Thus, while N-(2,6-dimethylphenyl)acetamide thrives in organic environments, its solubility challenges in polar solvents like water make it an interesting compound for study.

Interesting facts

Interesting Facts about N-(2,6-dimethylphenyl)acetamide

N-(2,6-dimethylphenyl)acetamide, commonly referred to as a derivative of acetamide, showcases fascinating characteristics that appeal to chemists and researchers alike. This compound belongs to a broader class of amides, known for their versatile applications in both industrial and biological contexts.

Chemical Nature and Characteristics

  • Functional Group: This compound features an acetamide functional group, which is a key component in many biological systems.
  • Structural Influence: The 2,6-dimethylphenyl substituent significantly influences the compound's reactivity and physical properties, making it an interesting study for drug design and synthesis.

Applications

The practical implications of N-(2,6-dimethylphenyl)acetamide are broad and multi-faceted:

  • Pharmaceutical Chemistry: Compounds like this often serve as intermediates in the synthesis of pharmaceuticals.
  • Research Compound: It is utilized in various research studies, particularly in understanding amide behaviors in biological systems.
  • Potential Biological Activity: There is ongoing exploration into the compound's biological activities, which may lead to new therapeutic agents.

Scientific Significance

The study of N-(2,6-dimethylphenyl)acetamide offers valuable insights into:

  • Amide Chemistry: Its unique structure contributes to understanding amide bonding and stability.
  • Synthetic Pathways: The routes to synthesize this compound are of significant interest, enabling chemists to develop more efficient methods for creating similar compounds.

As you delve deeper into the study of N-(2,6-dimethylphenyl)acetamide, remember the words of famed chemist Linus Pauling: "The best way to have a good idea is to have lots of ideas." Unlocking the mysteries of such compounds can lead to innovative discoveries and applications, potentially impacting various fields of science and technology.

Synonyms
N-(2,6-Dimethylphenyl)acetamide
2198-53-0
2,6-Dimethylacetanilide
2',6'-Dimethylacetanilide
2',6'-ACETOXYLIDIDE
N-Acetyl-2,6-xylidine
Acetamide, N-(2,6-dimethylphenyl)-
N-Acetyl-2,6-dimethylaniline
NSC 54130
Acetanilide, 2',6'-dimethyl-
68GZI4J9FM
N-Acetoxy-2,6-dimethylaniline
EINECS 218-596-8
NSC-54130
BRN 2208750
DTXSID2062244
LIDOCAINE IMPURITY C [EP IMPURITY]
LIDOCAINE HYDROCHLORIDE IMPURITY C [EP IMPURITY]
LIDOCAINE IMPURITY C (EP IMPURITY)
LIDOCAINE HYDROCHLORIDE IMPURITY C (EP IMPURITY)
DTXCID7036581
218-596-8
MFCD00008675
N-(2,6-dimethyl-phenyl)-acetamide
n-(2,6-dimethylphenyl)-acetamide
2,6-Acetoxylide
Lidocaine Hydrochloride Imp. C (EP); Lidocaine Imp. C (EP); N-(2,6-Dimethylphenyl)-acetamide; Lidocaine Hydrochloride Impurity C; Lidocaine Impurity C
NSC54130
Acetamide,N-(2,6-dimethylphenyl)-
Acetanilide,6'-dimethyl-
UNII-68GZI4J9FM
SCHEMBL436967
WLN: 1VMR B1 F1
N-(2, 6-dimethylphenyl)acetamide
N-(2,6-dimethylphenyl) acetamide
2',6'-Dimethylacetanilide, 97%
CGA42447
STK026386
2 inverted exclamation marka,6 inverted exclamation marka-Dimethylacetanilide
AKOS003237148
FD00780
SB75738
s10126
BS-16053
SY061310
CS-0153429
NS00027010
EN300-154494
AE-562/40191128
Q27264249
InChI=1/C10H13NO/c1-7-5-4-6-8(2)10(7)11-9(3)12/h4-6H,1-3H3,(H,11,12
2',6'-Dimethylacetanilide (Lidocaine RCC), Pharmaceutical Secondary Standard; Certified Reference Material