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Clemastine Fumarate

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Identification
Molecular formula
C21H26Cl2N2O3
CAS number
15686-51-8
IUPAC name
N-[(2R)-2-(4-acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide
State
State

At room temperature, the compound is typically a solid.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.20
Boiling point (Celsius)
305.50
Boiling point (Kelvin)
578.70
General information
Molecular weight
459.90g/mol
Molar mass
459.8990g/mol
Density
1.3871g/cm3
Appearence

The compound typically appears as a white powder or crystalline solid.

Comment on solubility

Solubility of N-[(2R)-2-(4-acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide

The solubility of N-[(2R)-2-(4-acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide can be quite intriguing due to its complex chemical structure. Several factors influence its solubility:

  • Polarity: The presence of functional groups, such as hydroxyl (-OH) and acetamide (-CONH2), generally increases polarity, which can enhance solubility in polar solvents like water.
  • Hydrophobic Interactions: The phenyl groups and the acetyl moiety may hinder solubility in water due to their hydrophobic nature, leading to decreased affinity for polar solvents.
  • Solvent Choice: The compound is likely to be more soluble in organic solvents (e.g., ethanol or acetone) compared to water, owing to its somewhat hydrophobic characteristics.

In summary, the solubility of this compound is a delicate balance influenced by its structure's hydrophilicity and hydrophobicity. As with many organic compounds, testing various solvents will provide the best insight into its solubility behavior.

Interesting facts

Interesting Facts about N-[(2R)-2-(4-acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide

N-[(2R)-2-(4-acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide is a fascinating compound worth exploring due to its unique structure and potential applications. Here are several intriguing aspects of this compound:

  • Synthetic Versatility: This compound features several functional groups which enable it to be synthesized through diverse pathways, facilitating its study in various chemical contexts.
  • Biological Relevance: It has gained attention for its potential therapeutic properties, possibly acting as an effective agent in treating specific health conditions, owing to its interaction with biological systems.
  • Chirality and Isomerism: The presence of the chiral center in the compound means that it can exist in multiple isomeric forms. This chirality often leads to differences in biological activity and can be crucial in pharmaceutical applications.
  • Environmental Considerations: As a chlorinated compound, its synthesis and degradation pathways can be particularly relevant in the field of environmental chemistry, prompting studies into its ecological impact and persistence.
  • Structure-Activity Relationship (SAR): The intricate structure of the compound offers a compelling basis for SAR studies, enabling researchers to ascertain how specific modifications might affect its activity and efficacy.

In summary, N-[(2R)-2-(4-acetylphenyl)-2-hydroxy-1-(hydroxymethyl)ethyl]-2,2-dichloro-acetamide is more than just a chemical entity; it is a key to unlocking various fields of research ranging from medicinal chemistry to environmental science. Its unique features make it a topic of ongoing scientific interest and inquiry.