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N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide

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Identification
Molecular formula
C18H16N6O
CAS number
776780-63-0
IUPAC name
N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide
State
State

At room temperature, the compound is a solid. It forms stable crystalline structures that do not readily decompose, making it suitable for various applications requiring solid state materials.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
305.00
Boiling point (Kelvin)
578.15
General information
Molecular weight
331.35g/mol
Molar mass
331.3530g/mol
Density
1.3190g/cm3
Appearence

The compound appears as a crystalline solid. It may slightly differ between shades of off-white to light beige depending on its purity and specific conditions.

Comment on solubility

Solubility of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide (C18H16N6O)

The solubility of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide can be described as follows:

  • Polar solvents: The presence of different functional groups, primarily the acetamide group, typically allows this compound to show a degree of solubility in polar solvents, such as water or methanol.
  • Non-polar solvents: In contrast, due to its significant aromatic components, it is expected to have better solubility in non-polar organic solvents like dichloromethane or toluene.
  • Temperature dependence: Solubility may increase with temperature; thus, solutions should be prepared at an elevated temperature for optimal dissolution.
  • pH influence: As an amide, its solubility might be affected by the pH of the solution, with potential ionization impacting its solubility in aqueous environments.

In summary, the solubility of this compound presents a dual nature, being more soluble in non-polar solvents while also exhibiting some degree of polar solubility due to functional group interactions. Understanding this behavior is crucial for its application in various chemical processes.

Interesting facts

Interesting Facts about N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide

N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide is a fascinating compound with intriguing properties and potential applications in various fields. Here are some noteworthy aspects:

  • Structure and Composition: This compound features a complex structure that incorporates elements of both pyrazolo and pyrimidine moieties, making it a subject of interest for medicinal chemistry.
  • Pharmacological Potential: Its design suggests that it may exhibit activity against specific biological targets, especially in the realm of cancer research, where both pyrazolo and pyrimidine derivatives have shown promise in anti-cancer therapies.
  • Cyanopyrazolo Influence: The presence of the cyanopyrazolo group could impart unique electronic properties to the molecule, potentially influencing its interactions with biological macromolecules.
  • Research Application: Compounds with similar frameworks have been investigated as signaling molecules or inhibitors in various metabolic pathways, thereby showcasing their importance in drug discovery.
  • Analytical Techniques: Studying this compound would typically involve advanced techniques such as NMR, HPLC, or mass spectrometry for characterizing its structure and purity.

This compound is part of a growing library of innovative molecules that are progressively aiding the quest for new therapeutic options. As noted by many chemists, "Structure determines function," and the unique features of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide exemplify this principle beautifully.

Synonyms
zaleplon
151319-34-5
Sonata
ZAL-846
CL-284846
SKP-1041
CL 284,846
Zaleplon civ
L846
LJC 10846
LJC-10846
N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide
zaleplone
L-846
DEA No. 2781
3'-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)-N-ethylacetanilide
UNII-S62U433RMH
S62U433RMH
DTXSID5023748
CHEBI:10102
N-(3-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide
3'-(3-Cyanopyrazolo(1,5-alpha)pyrimidin-7-yl)-N-ethylacetanilide
DTXCID103748
Zaleplon [USAN:USP:INN:BAN]
LJC10846
N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-N-ethylacetamide
NCGC00160525-01
ZALEPLON (MART.)
ZALEPLON [MART.]
Acetamide, N-(3-(3-cyanopyrazolo(1,5-alpha)pyrimidin-7-yl)phenyl)-N-ethyl-
ZALEPLON CIV (USP-RS)
ZALEPLON CIV [USP-RS]
ZALEPLON (USP MONOGRAPH)
ZALEPLON [USP MONOGRAPH]
CL 284846
Zaleplon (USAN:USP:INN:BAN)
ZAL 846
N-(3-{3-cyanopyrazolo[1,5-a]pyrimidin-7-yl}phenyl)-N-ethylacetamide
Staccato-zaleplon
SMR000238180
Sonata (TN)
CAS-151319-34-5
zaleplonum
Zaleplon AP
AZ-007
ZALEPLON [USAN]
ZALEPLON [INN]
ZALEPLON [JAN]
ZALEPLON [MI]
ZALEPLON [VANDF]
ZALEPLON [WHO-DD]
Acetamide, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethyl-
Zaleplon (JAN/USP/INN)
CHEMBL1521
ZALEPLON [EMA EPAR]
SCHEMBL29118
MLS000759451
MLS001424238
BIDD:GT0046
Zaleplon, 1mg/ml in Methanol
ZALEPLON [ORANGE BOOK]
GTPL4345
BDBM86521
N05CF03
Zaleplon 1.0 mg/ml in Methanol
HMS2052J11
HMS3394J11
HMS3713H08
BCP21340
CAS_5719
NSC_5719
Tox21_111872
MFCD00867990
N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide
Zaleplon, >=98% (HPLC), solid
AKOS000280863
Tox21_111872_1
AC-2082
CCG-101187
DB00962
NC00437
SS-4571
NCGC00160525-02
HY-14265
DB-015068
NS00006819
C07484
D00530
Z-0500
AB00640003_03
A809159
Q145052
SR-01000759426
SR-01000759426-3
BRD-K92657060-001-05-7
Zaleplon, United States Pharmacopeia (USP) Reference Standard
3'-(3-CYANOPYRAZOLO(1,5-.ALPHA.)PYRIMIDIN-7-YL)-N-ETHYLACETANILIDE
N-[3-(3-cyano-7-pyrazolo[1,5-a]pyrimidinyl)phenyl]-N-ethylacetamide
N-[3-(3-cyanopyrazolo-[1,5-a]-pyrimidin-7-yl)-phenyl]-N-ethyl acetamide
N-[3-(3-Cyanopyrazolo-[1,5-a]pyrimidin-7-yl)phenyl)-N-ethylacetamide
ACETAMIDE, N-(3-(3-CYANOPYRAZOLO(1,5-.ALPHA.)PYRIMIDIN-7-YL)PHENYL)-N-ETHYL-
1007130-22-4