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Phenacetin

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Identification
Molecular formula
C10H13NO2
CAS number
62-44-2
IUPAC name
N-(3-amino-4-ethoxy-phenyl)acetamide
State
State

At room temperature, Phenacetin is a solid. It is usually available as a crystalline powder.

Melting point (Celsius)
134.50
Melting point (Kelvin)
407.60
Boiling point (Celsius)
515.80
Boiling point (Kelvin)
789.00
General information
Molecular weight
179.22g/mol
Molar mass
179.2160g/mol
Density
1.2020g/cm3
Appearence

Phenacetin appears as a white crystalline solid or powder. It is typically odorless.

Comment on solubility

Solubility of N-(3-amino-4-ethoxy-phenyl)acetamide

N-(3-amino-4-ethoxy-phenyl)acetamide is a compound with properties that influence its solubility in various solvents. The solubility of this compound can be analyzed based on several key factors:

  • Polarity: The presence of the amino and ethoxy groups in the structure enhances its polarity, suggesting that it is more likely to dissolve in polar solvents such as water.
  • Hydrogen Bonding: The amino group (-NH2) can engage in hydrogen bonding with solvents, which may further increase its solubility.
  • Hydrophobic Effects: The ethoxy moiety may introduce some hydrophobic character, leading to varying solubility depending on the proportion of solvate and solvent interactions.
  • Temperature Dependence: Like many organic compounds, the solubility can be influenced by temperature; higher temperatures typically increase the solubility.

Overall, it can be said that the solubility of N-(3-amino-4-ethoxy-phenyl)acetamide is relatively favorable in polar solvents, while it may exhibit limited solubility in non-polar environments. This aligns with the general principle that compounds with polar functional groups tend to have higher solubilities in polar solvents.

Interesting facts

Interesting Facts about N-(3-amino-4-ethoxy-phenyl)acetamide

N-(3-amino-4-ethoxy-phenyl)acetamide is a fascinating compound with a range of applications and properties that intrigue chemists and pharmacologists alike. Here are some noteworthy aspects:

  • Biological Significance: This compound plays a role in drug discovery and development, primarily due to its potential as a scaffold in medicinal chemistry.
  • Pharmacological Insights: Research has indicated that N-(3-amino-4-ethoxy-phenyl)acetamide may exhibit anti-inflammatory and analgesic properties, making it of interest in the management of pain and inflammation.
  • Synthetic Versatility: The structure of this compound allows for various synthetic modifications, enhancing its utility in developing new pharmaceutical agents.
  • Structure-Activity Relationships: The specific arrangement of the amino and ethoxy groups influences its interaction with biological targets, making studies of its structure-activity relationship complex and intriguing.
  • Research Opportunities: Ongoing studies focus on understanding the mechanism of action and optimizing its efficacy, contributing to a deeper knowledge of compounds in its class.

In summary, N-(3-amino-4-ethoxy-phenyl)acetamide is a compound that not only serves as a valuable tool in synthetic and medicinal chemistry but also opens avenues for exciting research into its therapeutic potential. As emphasized by chemists: "The beauty of chemistry lies in uncovering the potential of seemingly simple compounds."


Synonyms
N-(3-AMINO-4-ETHOXYPHENYL)ACETAMIDE
3-Amino-4-ethoxyacetanilide
CCRIS 29
HSDB 5070
Acetamide, N-(3-amino-4-ethoxyphenyl)-
2-Amino-4-acetaminifenetol
2-Amino-4-acetaminifenetol [Czech]
EINECS 241-100-6
UNII-8W076B0J2D
3-Amino-4-ethoxyanilid kyseliny octove [Czech]
BRN 3545784
DTXSID7020053
8W076B0J2D
3'-AMINO-P-ACETOPHENETIDIDE
3-Amino-4-ethoxyanilid kyseliny octove
DTXCID1053
N-(3-AMINO-4-ETHOXYPHENYL)ACETAMIDE [HSDB]
2-AMINO-4-ACETAMINIFENETOL (CZECH)
3'-Amino-4'-Ethoxyacetanilide
2Amino4acetaminifenetol
3Amino4ethoxyacetanilide
Acetanilide, 3amino4ethoxy
pAcetophenetidide, 3'amino
5(Acetylamino)2ethoxyaniline
Acetamide, N(3amino4ethoxyphenyl)
3Amino4ethoxyanilid kyseliny octove
ACETANILIDE, 3-AMINO-4-ETHOXY
241-100-6
17026-81-2
p-Acetophenetidide, 3'-amino-
5-(Acetylamino)-2-ethoxyaniline
Acetanilide, 3'-amino-4'-ethoxy-
N-[3-amino-4-(ethyloxy)phenyl]acetamide
NCI-C01887
Acetanilide, 3-amino-4-ethoxy-
ACETAMIDE,N-(3-AMINO-4-ETHOXYPHENYL)-
MLS002415700
SCHEMBL2972710
CHEMBL1531976
XTXFAVHDQCHWCS-UHFFFAOYSA-N
HMS3039M13
Tox21_200653
AKOS006343297
NCGC00090849-01
NCGC00090849-02
NCGC00258207-01
SMR001370888
CAS-17026-81-2
DB-023323
NS00025582
Q26841337