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N,N’-bis(aziridinyl)-p-toluamide

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Identification
Molecular formula
C13H16N4O2
CAS number
52890-08-1
IUPAC name
N-[3-(aziridine-1-carbonylamino)-4-methyl-phenyl]aziridine-1-carboxamide
State
State

The compound is a crystalline solid at room temperature, indicating a stable structure with defined melting and boiling points which are significantly above room temperature.

Melting point (Celsius)
129.00
Melting point (Kelvin)
402.15
Boiling point (Celsius)
406.50
Boiling point (Kelvin)
679.65
General information
Molecular weight
232.28g/mol
Molar mass
232.2760g/mol
Density
1.2580g/cm3
Appearence

N,N’-bis(aziridinyl)-p-toluamide appears as a colorless to pale yellow crystalline solid. The compound is typically found in crystalline powder form and may exhibit a faint amine-like odor due to the aziridine groups present in the molecular structure.

Comment on solubility

Solubility of N-[3-(aziridine-1-carbonylamino)-4-methyl-phenyl]aziridine-1-carboxamide

The solubility of N-[3-(aziridine-1-carbonylamino)-4-methyl-phenyl]aziridine-1-carboxamide can be influenced by several factors, particularly its molecular structure and interactions with solvents. This compound, characterized by the presence of aziridine rings and various functional groups, showcases a unique behavior in different solvent systems.

Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups often enhances solubility in polar solvents, such as water and alcohols.
  • Hydrogen Bonding: Functional groups capable of forming hydrogen bonds can significantly increase solubility, particularly in aqueous environments.
  • Molecular Size: Larger and more complex molecules may exhibit reduced solubility compared to smaller, simpler counterparts.
  • pH: The solubility can also be affected by changes in pH, especially for compounds with acidic or basic functional groups.

In general, the solubility of compounds like N-[3-(aziridine-1-carbonylamino)-4-methyl-phenyl]aziridine-1-carboxamide can be described as:

  • Moderate to High: When dissolved in polar solvents due to favorable interactions.
  • Low: In non-polar solvents, which may lack the necessary interactions to dissolve the compound effectively.

Ultimately, understanding the solubility of this compound is crucial for its practical applications, especially in biochemical or pharmaceutical contexts, where solubility can impact bioavailability and efficacy.

Interesting facts

Interesting Facts About N-[3-(aziridine-1-carbonylamino)-4-methyl-phenyl]aziridine-1-carboxamide

This intriguing compound is part of the aziridine family, which is known for its unique three-membered ring structure that exhibits various biological activities. Here are some fascinating insights into this compound:

  • Potential Therapeutic Applications: Aziridine derivatives are often investigated for their potential as pharmaceuticals. They may possess properties such as antimicrobial, anticancer, and anti-inflammatory effects, making them of great interest in medicinal chemistry.
  • Structure-Activity Relationship (SAR): The presence of aziridine moieties in this compound may influence its reactivity and biological activity. The specific arrangement of functional groups can affect how the compound interacts with biological targets.
  • Reaction Characteristics: The aziridine ring can undergo various chemical transformations including ring-opening reactions, which allow for the synthesis of more complex molecules. This makes aziridine a versatile building block in organic synthesis.
  • Chemical Stability: The aziridine ring has unique properties that can contribute to the stability and reactivity of the compound under certain conditions. Understanding these properties is crucial for predicting the behavior of the compound in biological systems.
  • Research Focus: Continuous research is being conducted to uncover the full range of activities and mechanisms of action of such aziridine-containing compounds, which may lead to innovative drug design.

In conclusion, N-[3-(aziridine-1-carbonylamino)-4-methyl-phenyl]aziridine-1-carboxamide stands as a promising candidate in the vast world of chemical compounds, showcasing the importance of aziridine derivatives in research and potential applications.

Synonyms
2,4-Bis(3,3-ethyleneureido)toluene
ESK 230
Olin 53264
2,4-Tolylenebis(ethyleneurea)
2131-75-1
OM 53264
H75K4D33KK
NSC 26238
NSC-26238
BRN 0281630
AI3-50173
1-Aziridinecarboxamide, N,N'-(4-methyl-1,3-phenylene)bis-
1-AZIRIDINECARBOXAMIDE, N,N'-(4-METHYL-m-PHENYLENE)BIS-
DTXSID20175582
N,N'-(2,4-Tolylene)bis(1-aziridinecarboxamide)
N,N'-Bis-cycloethylenecarbamyl-2,4-diaminotoluene
N,N'-(4-Methyl-m-phenylene)bis(1-aziridinecarboxamide)
4-20-00-00020 (Beilstein Handbook Reference)
N,N'-(4-METHYL-1,3-PHENYLENE)BIS(1-AZIRIDINECARBOXAMIDE)
DTXCID8098073
MLS002639100
N,4-diaminotoluene
2,3-ethyleneureido)toluene
UNII-H75K4D33KK
SCHEMBL1610477
CHEMBL1698887
HMS3080G05
NSC26238
N,4-Tolylene)bis(1-aziridinecarboxamide)
SMR001548551
DS-008595
1-Aziridinecarboxamide,N'-(4-methyl-m-phenylene)bis-
1-Aziridinecarboxamide,N'-(4-methyl-1,3-phenylene)bis-
1-Aziridinecarboxamide,n,n-(4-methyl-1,3-phenylene)bis-