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N-(3-chloro-4-methylphenyl)acetamide

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Identification
Molecular formula
C9H10ClNO
CAS number
15118-76-0
IUPAC name
N-(3-chloro-4-methyl-phenyl)acetamide
State
State

At room temperature, N-(3-chloro-4-methylphenyl)acetamide is in a solid state. It is usually found in a crystalline form.

Melting point (Celsius)
125.40
Melting point (Kelvin)
398.55
Boiling point (Celsius)
274.10
Boiling point (Kelvin)
547.25
General information
Molecular weight
185.64g/mol
Molar mass
185.6490g/mol
Density
1.2284g/cm3
Appearence

N-(3-chloro-4-methylphenyl)acetamide is typically a solid compound. It can appear as a crystalline powder with a white to off-white color.

Comment on solubility

Solubility of N-(3-chloro-4-methyl-phenyl)acetamide

The solubility of N-(3-chloro-4-methyl-phenyl)acetamide in various solvents can be influenced by its unique chemical structure. This compound is expected to exhibit a moderate to good solubility in polar solvents due to the presence of the amide functional group. Here are some key points to consider:

  • Polar solvents: Compounds with amide groups generally show increased solubility in water and alcohols, as the amide can engage in hydrogen bonding.
  • Non-polar solvents: N-(3-chloro-4-methyl-phenyl)acetamide may have reduced solubility in non-polar solvents, as the hydrophobic characteristics of the aromatic ring can limit interaction with such solvents.
  • Temperature dependence: The solubility may increase with rising temperatures, as higher kinetic energy generally allows more successful interactions between solute and solvent molecules.

In summary, while the solubility profile of N-(3-chloro-4-methyl-phenyl)acetamide can be influenced by the solvent choice, it is generally regarded as soluble in polar environments. As stated in the classic principle of solubility, "like dissolves like," making this compound less favorable in non-polar conditions.

Interesting facts

Interesting Facts about N-(3-chloro-4-methyl-phenyl)acetamide

N-(3-chloro-4-methyl-phenyl)acetamide is a compound that attracts significant interest in the field of organic chemistry, particularly for its structural components and potential applications. Here are some notable aspects of this compound:

  • Structure and Functionality: This compound showcases a unique arrangement of atoms. The presence of a chloro group and a methyl group on the phenyl ring contributes to its chemical properties and biological activity.
  • Pharmaceutical Potential: Compounds like N-(3-chloro-4-methyl-phenyl)acetamide are often explored for their potential therapeutic applications. Due to the structure’s resemblance to certain pharmaceutical agents, it might play a role in the development of new drugs.
  • Versatile Reactivity: The functional groups attached to the acetamide moiety allow for a range of chemical reactions. These include nucleophilic substitutions and coupling reactions, making it a valuable intermediate in organic synthesis.
  • Importance in Research: As a subject of study in medicinal chemistry, this compound can help scientists understand structure-activity relationships (SAR) which is crucial for drug design.
  • Environmental Considerations: The presence of chlorine in this compound emphasizes the need for careful handling and analysis, as chlorine-containing compounds tend to have important environmental implications.

Overall, N-(3-chloro-4-methyl-phenyl)acetamide serves as an interesting example of how modifications in chemical structure can lead to diversity in functionality and potential applications. As researchers continue to explore such compounds, they pave the way for innovations in both organic chemistry and pharmacology.

Synonyms
N-(3-Chloro-4-methylphenyl)acetamide
7149-79-3
3-Chloro-4-acetotoluidide
o-Chloro-p-acetotoluidide
4-(Acetylamino)-2-chlorotoluene
3'-Chloro-p-acetotoluidide
DRC-2698
PRC-698
Acetamide, N-(3-chloro-4-methylphenyl)-
p-ACETOTOLUIDIDE, 3'-CHLORO-
EINECS 230-483-5
NSC 72333
BRN 2691932
X7X7S72D5R
DTXSID8042181
NSC-72333
DTXCID6022181
2-12-00-00530 (Beilstein Handbook Reference)
CHLORO-4-METHYLPHENYL)ACETAMIDE, N-(3-
230-483-5
3-chloro-4-methylacetanilide
N1-(3-chloro-4-methylphenyl)acetamide
3'-chloro,4'-methylacetanilide
UNII-X7X7S72D5R
NSC72333
MFCD00032582
Acetamide,N-(3-chloro-4-methylphenyl)-
Maybridge1_000129
MixCom1_000239
4-Acetamido-2-chlorotoluene
WLN: GR B1 EMV1
SCHEMBL864429
CHEMBL3186889
CS-M1325
HAA14979
Tox21_302189
AB6861
AKOS001044828
N-(3-Chloro-4-methyl-phenyl)-acetamide
NCGC00257550-01
CAS-7149-79-3
DB-074440
NS00037224
EN300-129987
9R-0661
AG-668/02843007
N~1~-(3-CHLORO-4-METHYLPHENYL)ACETAMIDE
Q27293653
Z28153679