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Amitriptyline

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Identification
Molecular formula
C20H23ClN2
CAS number
50-48-6
IUPAC name
N-(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-N',N'-dimethyl-propane-1,3-diamine
State
State

Amitriptyline is a solid at room temperature.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
599.60
Boiling point (Kelvin)
872.80
General information
Molecular weight
277.41g/mol
Molar mass
277.4100g/mol
Density
1.1001g/cm3
Appearence

Amitriptyline is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of N-(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-N',N'-dimethyl-propane-1,3-diamine

The solubility of N-(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-N',N'-dimethyl-propane-1,3-diamine presents fascinating characteristics due to its complex molecular structure. Understanding its solubility is vital for various applications, including formulation in pharmaceuticals and chemical reactions.

Factors Influencing Solubility:

  • Molecular Structure: The presence of functional groups such as amines and halogens can significantly affect solubility.
  • Polarity: The balance between polar and nonpolar regions within the compound influences its ability to dissolve in aqueous versus organic solvents.
  • Temperature: Higher temperatures generally increase solubility for most compounds, but specific interactions can vary.
  • Interactions: Hydrogen bonding and van der Waals forces play crucial roles in how well the compound interacts with solvents.

Experimental examinations often reveal that this compound may exhibit limited solubility in water due to its bulky structure and hydrophobic characteristics. However, it may dissolve more readily in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol, enabling effective applications in organic synthesis.

As quoted in the literature, "Solubility is the key to reactivity," highlighting the indispensable role that solubility plays in determining the effectiveness of a compound in various chemical processes. Understanding the solubility profile of this compound is crucial for maximizing its potential in practical applications.

Interesting facts

Interesting Facts about N-(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-N',N'-dimethyl-propane-1,3-diamine

This fascinating compound, known for its complex structure, is primarily of interest in medicinal chemistry due to its potential pharmacological applications. The compound features a unique bicyclic framework that contributes to its biological activity. Here are some intriguing aspects:

  • Structural Complexity: The presence of multiple rings and various functional groups makes this compound a candidate for studying interactions at a molecular level, especially in drug design.
  • Biological Activity: Compounds like this one may exhibit promising activities against specific targets in diseases, which is why they are often explored in the development of new therapeutics.
  • Chlorine Atom Influence: The chlorine substituent at the 3-position can significantly impact the compound's reactivity and bioactivity, enhancing its ability to engage in various chemical interactions within biological systems.
  • Synthesis Challenges: The synthesis of such intricate compounds is of great interest in organic chemistry, involving multiple steps that require careful optimization of reaction conditions.

As stated by one prominent researcher in the field, “The beauty of organic synthesis lies in the complexity that can be achieved through a careful dance of chemistry and creativity.” This compound embodies that philosophy, showcasing how sophisticated molecular architectures can lead to novel therapeutic avenues.

Additionally, the compound’s dual amine functionality allows for further modifications or conjugations, which can facilitate the synthesis of even more complex derivatives possibly enhancing the affinity for specific receptors or targets. The exploration of such derivatives could pave the way for innovative treatments in various fields of medicine.