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Bupropion

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Identification
Molecular formula
C13H18ClNO
CAS number
31677-93-7
IUPAC name
N-[3-(cyclohexylamino)propyl]-2-hydroxy-2-phenyl-acetamide
State
State

At room temperature, Bupropion is generally found in its solid form. This physical state is typical of many pharmaceutical compounds unless dissolved in an appropriate solvent for administration or analysis purposes.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
343.20
Boiling point (Kelvin)
616.35
General information
Molecular weight
255.10g/mol
Molar mass
239.3050g/mol
Density
1.2499g/cm3
Appearence

Bupropion is typically encountered as a white, crystalline powder that is relatively stable under standard conditions. The compound is known for its identifiable crystalline form that can vary slightly depending on the specific polymorphic state, but it generally appears as a fine, white powder.

Comment on solubility

Solubility of N-[3-(cyclohexylamino)propyl]-2-hydroxy-2-phenyl-acetamide

This compound, known as N-[3-(cyclohexylamino)propyl]-2-hydroxy-2-phenyl-acetamide, presents some interesting aspects regarding its solubility profile. Understanding its solubility is crucial for various applications, especially in pharmaceutical formulations.

Factors Influencing Solubility:

  • Polarity: The presence of the hydroxyl group (-OH) and amine group (-NH) suggests that the compound is likely to exhibit some level of polarity, which can enhance its solubility in polar solvents like water.
  • Hydrophobic Interactions: The cyclohexyl group contributes a considerable hydrophobic character, potentially reducing overall solubility in aqueous environments.
  • Temperature Dependence: Solubility may increase with temperature, as is typical for many compounds, allowing for greater interaction with solvents.

As a result, one might expect partial solubility in water while demonstrating better solubility in organic solvents such as methanol or ethanol. This behavior can be summarized in the following points:

  • **Moderate solubility in polar solvents** due to polar functional groups.
  • **Higher solubility in organic solvents** due to the lipophilic cyclohexyl portion.
  • **Potential for solubilization enhancement** through the use of co-solvents or surfactants, which can help stabilize and improve the overall solubility profile.

In conclusion, while N-[3-(cyclohexylamino)propyl]-2-hydroxy-2-phenyl-acetamide displays a complex solubility behavior dictated by its molecular structure, understanding these characteristics is essential for its successful application in various fields.

Interesting facts

Interesting Facts About N-[3-(cyclohexylamino)propyl]-2-hydroxy-2-phenyl-acetamide

N-[3-(cyclohexylamino)propyl]-2-hydroxy-2-phenyl-acetamide is an intriguing compound with a variety of fascinating attributes that make it notable in the fields of chemistry and pharmacology. This compound belongs to the class of amides, which are known for their utility in both synthetic chemistry and in biological systems.

Key Features:

  • Mechanistic Insights: As an amide, this compound can be involved in various reactions such as nucleophilic acyl substitution, making it a valuable starting material in organic synthesis.
  • Biological Relevance: The presence of the cyclohexylamino group is significant as it may influence the compound's interactions with biological targets, potentially resulting in interesting pharmacological activities.
  • Structural Diversity: The structural elements of this compound, particularly the cyclohexyl and phenyl groups, contribute to its unique properties, such as steric hindrance and electronic effects, which may affect its reactivity and interactions.
  • Potential Applications: Compounds like this one are often investigated for their potential therapeutic effects, including analgesic or anti-inflammatory properties, making them of interest in drug development.

Moreover, such compounds highlight the synergy between synthetic organic chemistry and biological science. As researchers delve deeper into the complexities of these molecules, compounds like N-[3-(cyclohexylamino)propyl]-2-hydroxy-2-phenyl-acetamide could pave the way for discoveries in medicinal chemistry aimed at treating various diseases.

Quote from a renowned chemist: “The beauty of chemistry lies not just in the molecules we create, but in the potential they hold for improving lives.” This encapsulates the spirit of exploration that surrounds compounds like this one, showcasing their full potential awaiting discovery.

Synonyms
N-(3-(Cyclohexylamino)propyl)mandelamide
Mandelsaeure-(gamma-zyklohexylaminopropyl)-amid [German]
3118-61-4
MANDELAMIDE, N-(3-(CYCLOHEXYLAMINO)PROPYL)-
Mandelsaeure-(gamma-zyklohexylaminopropyl)-amid
DTXSID60953260
N-[3-(Cyclohexylamino)propyl]-2-hydroxy-2-phenylethanimidic acid